基于上皮间质转化的人参活性成分抗肿瘤作用的研究进展

上皮间质转化(epithelial-mesenchymal transition,EMT)是胚胎发育、细胞纤维化及肿瘤转移过程中的重要环节,其因可促进肿瘤细胞侵袭和扩散而成为肿瘤转移的关键促进剂,也是许多肿瘤的最终病理变化过程。在EMT过程中,上皮细胞失去极化结构并获得迁移和侵袭能力,导致肿瘤转移,是造成恶性肿瘤临床治疗失败且死亡率高的重要原因之一。研究表明,人参活性成分在不同类型肿瘤的EMT过程中均可发挥抑制作用,具有较好的临床疗效且不良反应少。因此,总结人参活性成分通过抑制EMT过程的抗肿瘤作用,以期为肿瘤治疗提供新思路以及为新型抗肿瘤中药的开发提供支撑。

Research progress on antitumor effects of active components from Panax ginseng based on epithelial interstitial transformation

Epithelial-mesenchymal transition (EMT) is an important link in the process of embryonic development, cell fibrosis and tumor metastasis. It can promote tumor cell invasion and spread and become a key promoter of tumor metastasis. It is also the final pathological change of many tumors. During the EMT process, epithelial cells lose their polarized structure and gain the ability to migrate and invade, leading to tumor metastasis, which is one of the important reasons for the failure of clinical treatment of malignant tumors and the high mortality rate. Studies have shown that active components from Panax ginseng can play an inhibitory role in the EMT process of different types of tumors, with good clinical efficacy and few adverse reactions, which provide a new idea for the treatment of tumors by inhibiting EMT. Therefore, research progress on anti-tumor effects of active components from Panax ginseng based on epithelial interstitial transformation is summarized in this paper, hoping to provide new ideas for tumor therapy and support for the development of new anti-tumor traditional Chinese medicine.