食管小细胞癌的临床病理,免疫组化及电镜观察

目的：探计食管小细胞瘤的临床病理特征、抗原表达及超微结构特点。方法：收集食管小细胞癌２８例，分析统计临床病理资料，每例均采用ＳＬＡＢ方法做７项免疫学标记，分别为ＣＫ、ＬＣＡ、Ｓ－１００，ＣＤ５６（神经细胞粘连分子）、ＣＨＡ（铬粒素）、ＮＳＥ（神经特异性烯醇化酶）、ＨＨＦ３５，５例取新鲜组织做电镜观察。结果：患者年龄以中老年多见，部位在中下段，病情发展快、转移早，预后差。林体形态为溃疡型、隆起型，镜

Clinicopathologic immunohistochemical and ultrastructural observation on small cell carcinomas of the esophagus

?Purpose:Small cell carcinomas (SCC) of the esophagus are rare and its clinicopathological and immunohistochemical and ultrastructurall characteristics were investigated. Methods:28 cases of SCC of the esophagus were detected,aged from 37 to 68 years old,the tumors were located mostly in the middle and lower segment of the esophagus.Results:They showed characteristics such as rapid development,early metastasis and poorer prognosis.Under microscopy,two types of SCC,i.e. oat-type(15/28) and non oat-type (13-28) were divided.Immunohistochemistry showed:CHA was positive in 96.4%,CD56 in 96.4% and NSE in 75%,while staining of CK,LCA,S-100,HHF35 were all negative.Neuroendocrine particles were present in tumor cells in all of 5 cases examined by electric microscopy.Conclusions:SCC of the esophagus is a highly malignant neuroendocrine tumor.These results suggested that CD56,CHA and NSE are useful and sensitive markers and electron microscopic observation may be of confirmative significance in the diagnosis.