辛伐他汀强化治疗对急性冠脉综合征患者炎症状态及氧化应激水平的影响

目的:观察辛伐他汀强化治疗对急性冠脉综合征患者血浆炎症状态及氧化应激水平的影响。方法:选取64例急性冠脉综合征患者,随机分为2组,常规治疗组服用20mg常规剂量辛伐他汀,强化治疗组患者于住院期间服用40mg强化治疗,出院后服用20mg治疗。并设健康对照组(无任何干预措施)。服药前后检测C反应蛋白(CRP)、丙二醛(MDA)、过氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)。结果:2组患者治疗后各项指标均较治疗前显著改善(P<0.05)。强化治疗组与常规治疗组患者血浆中MDA、SOD水平、GSH-Px活性在出院时即有显著性差异(P<0.05),CRP水平在出院后第4周时有显著性差异(P<0.05),出院8周后2组间上述所有指标间差异仍有统计学意义(P<0.05),出院12周时,差异无统计学意义(P>0.05)。结论:大剂量辛伐他汀短期强化治疗抗炎和抗氧化应激的保护作用更明显。

Effects of Intensive Simvastatin Treatment on Inflammation and Oxidative Stress in Patients with Acute Conoary Syndrome

OBJECTIVE:To investigate the effect of intensive simvastatin treatment and conventional treatment for inflammation and oxidative stress in patients with acute coronary syndrome.METHODS:64 patients with acute coronary syndrome were randomly divided into 2 groups,and conventional treatment group was given conventional dose of simvastatin 20 mg and intensive treatment group was given intensive treatment of simvastatin 40 mg,and healthy control group without any interventions.The CRP,MDA,SOD and GSH-Px were determined before and after treatment.RESULTS:The levels of MDA and SOD,GSH-Px activity were significant different between intensive treatment group and conventional treatment group(P<0.05),when the patients were discharged.But the difference of CRP levels was found in two groups after 4 weeks(P<0.05).After 8 weeks,the difference between 2 groups exited between 2 groups(P<0.05).After 12 weeks,the difference between 2 groups had no statistical difference(P>0.05).CONCLUSION:Intensive simvastatin treatment can protect patients with acute coronary syndrome patients from inflammation and oxidative stress,compared with conventional treatment.