Insulin-related metabolism following hematopoietic stem cell transplantation in childhood期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Insulin-related metabolism following hematopoietic stem cell transplantation in childhood

Authors:	Elhasid Ronit Leshem Yael A Ben Arush Myriam Weyl Rowe Jacob M Shehadeh Naim

Affiliation:	Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel;;Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel;;Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel;;and Department of Pediatrics A, Rambam Health Care Campus, Haifa, Israel

Abstract:	Objectives: To assess insulin-related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood. Study design: Thirty-four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow-up was 3.6 yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A_1c (HbA_1c) and lipid profile were measured and compared. Results: HbA_1c was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group. Conclusions: Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.

Keywords:	bone marrow transplantation DM glucose intolerance thalassemia
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