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P27和skp2在肝细胞癌中的表达及其意义
引用本文:邵馨,顾春燕. P27和skp2在肝细胞癌中的表达及其意义[J]. 临床肝胆病杂志, 2009, 25(2): 120-121
作者姓名:邵馨  顾春燕
作者单位:1. 常州市中医医院病理科,江苏,常州,213003
2. 南通大学附属南通第三医院病理科,江苏,南通,226006
摘    要:
目的探讨肝细胞癌P27和skp2蛋白的表达情况与临床病理意义。方法用免疫组化二步法检测P27和skp2在60例肝细胞癌及20例癌旁组织中的表达。结果60例肝细胞癌P27的阳性表达率为23%(14/60),癌旁组织为80%(16/20),60例肝细胞癌高分化癌阳性表达率为47%(7/15),低分化癌为16%(7/45)。P27在肝细胞癌中的表达明显低于癌旁组织,P27蛋白的表达随病理分级增高而降低。60例肝细胞癌skp2阳性表达率为47%(28/60),癌旁组织为15%(3/20),60例肝细胞癌高分化癌阳性表达率13%(2/15),低分化癌为58%(26/45),可见skp2在肝细胞癌中表达明显高于癌旁组织(P〈0.05),低分化癌明显高于高分化癌(P〈0.01)。结论P27和skp2蛋白的表达情况与肝细胞癌的发生发展及恶性度有关。

关 键 词:肝细胞癌  P27  skp2  免疫组织化学

Expression and significance of P27 and skp2 proteins in hepatocellular carcinoma
SHAO Xin,GU Chun-yan. Expression and significance of P27 and skp2 proteins in hepatocellular carcinoma[J]. Chinese Journal of Clinical Hepatology, 2009, 25(2): 120-121
Authors:SHAO Xin  GU Chun-yan
Affiliation:Department of Pathology;Changzhou Chinese Medicine Hospital;Changzhou Jiangsu 213003;China
Abstract:
Objective To explore the expression and significance of P27 and skp2 proteins in hepatocellular carcinoma(HCC).Methods Immunohistochemical(S-P)method was used to detect the expression of P27 and skp2 proteins in the 60 patients with HCC and 20 cases of peri-cancer tissues.Results The positive rate of P27 protein in 60 cases of hepatocellular carcinoma was 23%,that in the adjacent tumor tissue was 80%,The positive rate of p27 protein expression was significantly lower in tumor than in adjacent tumor tissue.T...
Keywords:P27  skp2
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