Increased prenatal blood manganese may induce gestational blood pressure |
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| Authors: | Mohsen Vigeh Emiko Nishioka Kazuhito Yokoyama Katsumi Ohtani Takehisa Matsukawa |
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| Affiliation: | 1. Department of Occupational Epidemiology, National Institute of Occupational Safety and Health, Kawasaki, Japan;2. Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Tokyo, Japan;3. Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Tokyo, Japan |
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| Abstract: | Objective: Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined. Methods: To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined. Results: Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation. A significant association between odds of pre-hypertension with blood Mn was shown (OR:1.150, 95% CI:1.052–1.258). Conclusion: The current study results might suggest the blood Mn level during early stage of pregnancy as a potential risk factor for increasing the risk of gestational blood pressure. |
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| Keywords: | Manganese blood pressure pre-hypertension pregnancy prenatal |
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