Long-term outcomes using vascular grafts sealed with fragmented autologous adipose tissue for aortoiliac occlusive disease |
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Authors: | Ichiya Yamazaki MD PhD Norihisa Karube MD PhD Tamitaro Soma MD Yasuharu Noishiki MD PhD Yukio Ichikawa MD PhD |
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Institution: | (1) Department of Cardiovascular Surgery, Saiseikai Yokohama Nanbu Hospital, 3-2-10 Kounandai, Kounan-ku, Yokohama 234-8503, Japan;(2) Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan |
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Abstract: | The aim of this study was to test the safety and efficacy of fragmented autologous adipose tissue (FAT) grafts for revascularization in aortoiliac occlusive disease. Twenty-seven patients with atherosclerotic aortoiliac occlusive disease underwent surgical treatment using FAT grafts. A piece of adipose connective tissue was obtained from the operative wound, cut into small pieces, and pressed into the wall of a fabric vascular prosthesis. Cumulative primary patency rates were 92% at 1 year, 92% at 3 years, and 86% at 6 years. Cumulative secondary patency rates were 96%, 96%, and 90% for the same intervals. In this clinical study, the FAT grafts demonstrated good long-term patency rates and no particular problems. This is the first clinical report of long-term outcomes using FAT grafts for aortofemoral or aortoiliac bypasses. FAT grafts are thus safe for revascularization in aortoiliac occlusive disease. |
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Keywords: | Vascular grafts Adipose tissue Aortoiliac occlusive disease Tissue engineering |
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