肝硬化患者骨密度及骨代谢变化分析

目的:探讨肝硬化child分级与骨密度(BMD)及骨代谢的关系,为防治肝硬化患者出现骨质疏松(OP)提供科学依据。方法:采用QCT骨密度测量仪对47例肝硬化患者和36例健康男性的BMD进行检测,同时测定血清甲状旁腺素(PTH)、骨钙素(BGP)、血清Ca和P水平。结果:随肝硬化肝功损害程度的加重,BMD、BGP、Ga、P均降低,PTH升高。结论:BMD降低是长期慢性肝病缓慢作用所致,故提倡在治疗肝硬化同时,也要进行预防OP的治疗。

Variation Analyse of The Bone Mineral Density And Metabolism of The Patient With Cirrhosis of The Liver

Objective:Discuss the relationship among child pugh grading,bone mineral density(BMD) and bone metabolism.In order to provide the scientific proof to prevent the patient with cirrh osis of the liver from occurring the osteoporosis(OP).Methods:Measure the BMD of 47 subjects with cirrbosis of the liver and 36 healthy man subjects by QCT bone mineral density surveyor,along with determine blood serium parathyroid hormone(PTH),osteocalcin(BGP),blood calcium and serum inorganic phosphorus.Results:lead to the significant reduction of BMD,BGP,blood calcium and serum inorganic phosphorus and the significant elevation of PTH following the liver function impairment degree get worse and worse.Conclusions:The significant reduction of BMD is the end results of the gradual action of the prolonged chronic hepatic ill,thus advocate the prophylactic therapy of OP in the meantime we treat cirrhosis of the liver.