| 17-丙烯胺基-17-去甲氧基格尔德霉素对鼻咽癌细胞VEGF和Survivin表达的影响 |
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| 引用本文： | 刘涛. 17-丙烯胺基-17-去甲氧基格尔德霉素对鼻咽癌细胞VEGF和Survivin表达的影响[J]. 延安大学学报(医学科学版), 2011, 9(1): 1-2,18 |
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| 作者姓名： | 刘涛 |
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| 作者单位： | 延安大学附属医院耳鼻咽喉科,陕西,延安,716000 |
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| 基金项目： | 2007年延安市科学技术项目 |
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| 摘 要： | 目的探讨17-丙烯胺基-17-去甲氧基格尔德霉素（17-AAG）对人鼻咽癌细胞（HNE1）的影响。方法采用流式细胞技术检测不同浓度（17-AAG）、不同时间处理后HNE1细胞凋亡情况,组织免疫细胞技术检测药物处理后对VEGF、Survivin蛋白表达的影响。结果 17-AAG可以诱导人鼻咽癌细胞的凋亡,且这种作用具有时间和计量依赖性,且可抑制细胞中VEGF、Survivin蛋白的表达。结论热休克蛋白抑制剂17-AAG具有诱导鼻咽癌细胞凋亡的作用,对鼻咽癌的临床治疗具有一定的指导意义。
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| 关 键 词： | 17-丙烯胺基-17-去甲氧基格尔德霉素（17-AAG） 鼻咽癌细胞 VEGF Survivin |
Effects of 17-allylamino-17-demethoxygeldanamycin on the expression of VEGF and Survivin proteins in human nasopharyngeal carcinoma cells |
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| LIU Tao. Effects of 17-allylamino-17-demethoxygeldanamycin on the expression of VEGF and Survivin proteins in human nasopharyngeal carcinoma cells[J]. Journal of Yanan University:Medical Science Edition, 2011, 9(1): 1-2,18 |
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| Authors: | LIU Tao |
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| Affiliation: | LIU Tao (Department of otorhinolaryngology,the first Affiliated Hospital of Yanan Unversity,Yanan 716000,China) |
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| Abstract: | Objective To explore the effects of 17-allylamino-17-demethoxygeldanamycin(17-AAG) on human nasopharyngeal carcinoma HNE1 cells.Methods Flow cytometry was used to detect apoptosis of HNE1 cells treated with 17-AAG with different concentration and at different time.Immunohistology was used to detect the expression of VEGF and Survivin proteins after drug treatment.Results 17-AAG induced apoptosis of human nasopharyngeal carcinoma HNE1 cells,which was doze and time dependent.17-AAG also inhibited he expressio... |
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| Keywords: | VEGF Survivin |
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