| 肾组织中降钙素基因相关肽与糖尿病大鼠早期肾损害的相关性研究 |
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| 引用本文： | 孟德欣,贾秀月,邢德刚,李翠玲.肾组织中降钙素基因相关肽与糖尿病大鼠早期肾损害的相关性研究[J].黑龙江医药科学,2002,25(6):7-7. |
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| 作者姓名： | 孟德欣 贾秀月 邢德刚 李翠玲 |
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| 作者单位： | 佳木斯大学基础医学院生理教研室,佳木斯,154007 |
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| 摘 要： | 目的：观察糖尿病大鼠肾组织中CGRP的含量变化与24h尿微量白蛋白的关系，为早期防治DN提供理论依据。方法：Wistar大鼠，体重160-200g，于造成糖尿病大鼠模型后第6、8、10、12、14周测定肾组织中的CGRP和24h尿微量白蛋白。结果：肾组织中的CGRP在造模后第6周无明显改变，第8周开始呈进行性下降，并与24h尿微量白蛋白呈显著负相关。结论：动态观察肾组织中CGRP的变化对于DN的早期发现及分析病情有重要意义。
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| 关 键 词： | 肾组织 降钙素基因相关肽 大鼠 相关性 糖尿病 糖尿病肾病 |
| 文章编号： | 1008-0104(2002)06-0007-01 |
| 修稿时间： | 2002年9月3日 |
Relationship between ship kidney tissue CGRP and early kidney injury in diabetic rats |
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| MENG Dexin,JIA Xiuyue,XING Degang,LI Cuiling.Relationship between ship kidney tissue CGRP and early kidney injury in diabetic rats[J].Heilongjiang Medicine and Pharmacy,2002,25(6):7-7. |
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| Authors: | MENG Dexin JIA Xiuyue XING Degang LI Cuiling |
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| Institution: | Basic Medical College of Jiamusi University Jiamusi 154007 |
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| Abstract: | Objective: To provide theoretical basis for preventing early injury of kidney, we observed the relationship between the alteration in CGRP of kidney tissue in diabetic rats and the quantity of uric micro-albumin in 24h. Methods: In wistar rats, weight 160~200g, the CGRP content of kidney tissue in diabetic rats and the quantity of uric micro-albumin in 24h at the 6th,8th,10th,12th and 14th weeks were assayed after they were the models of diabetic rats. Results: The CGRP content of kidney tissue in diabetic rats did not obviously alter at the 6th week but it evidently declined at the 8th week and related to the quantity of uric micro-albumin in 24h. Conclusions: The alteration of CGRP of kidney tissue in diabetic rats is significance on early discovering and analyzing DN. |
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| Keywords: | CGRP DM DN |
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