91例甲状腺间变癌临床分析

1954年～1990年收治91例甲状腺间变癌,约占全部甲状腺恶性肿瘤的5.85%.其恶性程度表现为14.29%,5年生存活率及26.08月平均存活期.ATC多发生于结节性甲状腺肿及分化型甲状腺癌,约56.04%的病人为50岁以上.如病人年龄在50岁以下,肿瘤较局限,肿瘤直径<5cm,无局部或远处转移者预后较佳.对于较局限的肿瘤,应行广泛切除,明显改善其预后.放疗或化疗以及综合治疗,其预后的效果值得进一步探讨.

Anaplastic Thyroid Carcinoma: A Clinical Study of 91 Cases

From 1954 to 1990, 91 patients with anaplastic thyroid carcinoma (ATC) were seen at Tianjin Cancer Hospital. It accounted for 5. 85% of all thyroid malignancies admitted in the hospital. Its lethality is evidenced by a 5-year survival rate of 14. 29% and a median survival of 26. 08 months. ATC has a higher co-incidence of goiter or well-differentiated thyroid carcinoma. About 56. 04% of ATC occurred in patients of 50 years of age or older. Relatively favorable prognostic features seemingly to be less than 50 years of age, unilateral tumors, tumor diameter of less than 5cm, void of invasion of adjacent tissue, and absence of regional and distant metastases. For resectable lesions, thyroid lobectomy with wide excision of adjacent soft tissue seems to be reasonably aggressive surgical approach. The value of radiotherapy, chemotherapy and combination of radiotherapy and chemotherapy need further study. No significant effect of these modalities was seen in this group.