| 食管癌倍体异质性分析的临床意义 |
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| 引用本文： | 周振英 蒋明. 食管癌倍体异质性分析的临床意义[J]. 实用癌症杂志, 1996, 11(1): 15-17 |
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| 作者姓名： | 周振英 蒋明 |
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| 作者单位： | 江苏省肿瘤防治研究所 |
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| 摘 要： | 作者采用流式细胞测量术（ＦＣＭ）对３０例食管癌患者１５０份样品进行了ＤＮＡ倍体异质性分析。结果表明，患者癌中心灶ＤＮＡ倍性异质体的检出率为５３．３％。ＤＮＡ倍性异质体和同质体患者癌中心灶和癌旁粘膜组织细胞的生物学特性均明显不同。患者癌中心灶倍性异质体的检出率随癌组织分级、肿瘤体积和癌细胞浸润深度的增加而升高（ｒ＞ｒ０．０５）。ＤＮＡ倍性异质体患者的存活时间显著短于同质体患者（Ｐ＜０．０５）；而异质体患者的死亡率却显著高于同质体患者（Ｐ＜０．０５）。
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| 关 键 词： | 流式细胞测量术，DNA含量，倍体异质性，食管癌 |
Clinical Signification of Analysis of Heterogeneity of DNA Content in Esophageal Carcinoma |
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| Zhou Zhenying,Jiang Ming,Zhang Junni, et al. Clinical Signification of Analysis of Heterogeneity of DNA Content in Esophageal Carcinoma[J]. The Practical Journal of Cancer, 1996, 11(1): 15-17 |
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| Authors: | Zhou Zhenying Jiang Ming Zhang Junni et al |
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| Abstract: | Heterogeneity of DNA content was analyzed in 120 samples from 30 patients with esophageal carcinoma.Results showed that the positive rate of heterogeneity of DNA content was 53.3%in the cancer nests of patients. Biological characteristics of cells in the cancer nests and para-cancer tissues was different bewteen heterogeneity cases and homogeneity cases.The positive rates of heterogeneity of DNA content were raised with increasing of histopathological grades, size of tumor and infiltrating deep of cancer cells (r>r0.05).The survival time of cases with heterogeneity of DNA content was shorter than that of cases with homogeneity(P<0.05),while death rate of cases with heterogeneity of DNA content was higher than that of cases with homogeneity(P<0.05). |
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| Keywords: | Flow cytometry DNA content Heterogeneity Esophageal carcinoma |
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