| 龙牙楤木总甙的抗炎作用 |
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| 引用本文： | 周重楚,孙晓波,刘威,高洪波,师海波,王桂英,杨竟平.龙牙楤木总甙的抗炎作用[J].中国药理学与毒理学杂志,1991(1). |
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| 作者姓名： | 周重楚 孙晓波 刘威 高洪波 师海波 王桂英 杨竟平 |
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| 作者单位： | 吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，延吉制药厂，白求恩医科大学 长春 130021，长春 130021，长春 130021，长春 130021，长春 130021 |
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| 摘 要： | 龙牙楤木总甙(As)显著抑制大鼠角叉菜胶、甲醛、热烫、PGE_2和组胺性足肿胀。对制霉菌素、5-HT引起大鼠足肿胀有一定抑制作用。抑制巴豆油气囊肿渗出和肉茅组织增生,抑制PGE_2、组胺、5-HT引起的毛细血管通透性增加。抑制白细胞游走,并能提高清除自由基的能力。其抗炎作用不依赖于垂体-肾上腺皮质系统,但对肾上腺皮质有一定刺激作用。
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| 关 键 词： | 龙牙揔木总甙 炎症 抗炎剂 |
Anti-inflammatory effect of aralosides |
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| ZHOU Chong-Chu,SUN Xiao-Bo,LIU Wei,GAO Hong-Bo,SHI Hai-Bo,WANG Gui-Ying,YANG Jing-PingDept Pharmacology.Anti-inflammatory effect of aralosides[J].Chinese Journal of Pharmacology and Toxicology,1991(1). |
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| Authors: | ZHOU Chong-Chu SUN Xiao-Bo LIU Wei GAO Hong-Bo SHI Hai-Bo WANG Gui-Ying YANG Jing-PingDept Pharmacology |
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| Institution: | ZHOU Chong-Chu,SUN Xiao-Bo,LIU Wei,GAO Hong-Bo,SHI Hai-Bo,WANG Gui-Ying,YANG Jing-PingDept Pharmacology,Institute of Chinese Materia Medica,Academy of Traditional Medicine and Materia Medica of Jilin Province,Changchun 130021 |
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| Abstract: | Aralosides was extracted from the bark of stem and root of Aralia elata (Miq) Seem. We have studied the anti-inflammatory effect of aralosides.It suppressed significantly the swelling of rat hind paw induced by carrageenin in both intact and adrenalectomized rats, the swelling induced by PGE2, histamine, 5-HT, formaldehyde and mycostatin and the scald oedema induced by scalding rat's hind paw. Aralosides had marked inhibitory effect on the increas sed permeability of capillaries caused by id PGE2, histamine, 5-HT, on the proliferation of granulation and exudation of air granuloma induced by croton oiland on the leukocytic migratory response.The content of PGE2, histamine and acid phosphatase in the inflammatory exudate formed by carrageenin, dextran and mycostatin was decreased markedly by ig aralosides. The extract decreased obviously the content of malondialdehyde (MDA) in hepatic tissue of intoxicated mice induced by alcohol and increased noticeably the activity of catalase (CAT) in hepatic tissue of mice and superoxide dismutase (SOD) in serum of rats. |
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| Keywords: | aralosides inflammation anti-inflammatory agent |
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