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| bFGF对大鼠皮瓣组织中SOD,MDA和NO的影响 | |
| 引用本文： | 王亚平 许明火. bFGF对大鼠皮瓣组织中SOD,MDA和NO的影响[J]. 军医进修学院学报, 1997, 18(2): 125-127 |
| 作者姓名： | 王亚平 许明火 |
| 作者单位： | [1]解放军304医院创伤研究室 [2]解放军304医院烧伤整形科 |
| 摘 要： | 本实验将碱性成纤维细胞生长因子（ｂＦＧＦ）应用于大任意皮瓣，观察ｂＦＧＦ对缺血皮瓣的坏死率，皮瓣局部组织中超氧化歧化酶（ＳＯＤ），丙二醛（ＭＤＡ）和一氧化氮（ＮＯ）含量的影响，初步探讨ｂＦＧＦ对皮瓣存活的作用机制。结果显示：ｂＦＧＦ治疗组与肝素盐水组比较；（１）皮瓣坏死率明显降低，皮瓣下肉芽组织层明显增厚，毛细血管和成纤维细胞明显增多；（２）中，远段皮瓣中ＳＯＤ含量术后２４ｈ，４８ｈ明显升高；（３ |
| 关 键 词： | 细胞生长因子 皮瓣 超氧化物歧化酶 一氧化氮 |
The effects of basic fibroblast growth factor on SOD, MDA and NO in skin flap tissues of rats |
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| Wang Yaping,Xu Minghuo,Fu Xiaobing,Sun Tongzhu. The effects of basic fibroblast growth factor on SOD, MDA and NO in skin flap tissues of rats[J]. Academic Journal of Pla Postgraduate Medical School, 1997, 18(2): 125-127 | |
| Authors: | Wang Yaping Xu Minghuo Fu Xiaobing Sun Tongzhu |
| Abstract: | An animal model of caudally based random skin flap was established in 54 Wistar rats to observe the effects of bFGF on skin flap survial, SOD, MDA and NO in skin flap tissues. The results showed that in bFGF treated group, flap necrosis was significantly lower, MDA and NO reduced significantly, and SOD elevated at the middle and distal parts as compared with those in the control group. These findings suggest that bFGF treatment may result in an improvement of the ischemic flap survival and an alleviation of the lipid peroxidation. |
| Keywords: | fibroblast growth factor surgical flaps SOD MDA NO |
| 本文献已被 CNKI 维普 等数据库收录！ | |