小青龙颗粒对支气管哮喘患者外周血Th17/Treg平衡影响的研究

目的探讨小青龙颗粒对支气管哮喘患者外周血Th17/Treg平衡的影响。方法将60例支气管哮喘急性发作期患者随机分为2组:治疗组给予小青龙汤治疗,对照组给予西医常规治疗组,治疗7 d后评定疗效。治疗前后采集标本进行Th17细胞、Treg细胞检测。结果 2组治疗后外周血Th17细胞百分率和Th17/Treg细胞的比值均下降,Treg细胞的百分率均上升;治疗后治疗组外周血IL-17细胞百分率、IL-17/TGF-β1的比值均低于对照组,TGF-β1细胞百分率高于对照组。结论小青龙颗粒可有效调控Th17/Treg失衡,在支气管哮喘发作期治疗和调节免疫上有应用价值。

Study of the effect of Xiaoqinglong Particles on Th17/Treg balance in peripheral blood of asthma patients

Objective It is to explore the effect of Xiaoqinglong Particles on Thl7/Treg balance in peripheral blood of Asthma patients.Methods 60 patients with acute bronchial asthma were randomly divided into two groups: the treatment group was treated with Xiaoqinglong particles,and the control group was treated with conventional western medicine.After 7 days’ treatment,the curative effects in both groups were evaluated.The study sample was collected to determine Th17 cells and Treg cells before and after treatment.Results After treatment the percentage of Th17 cells and Th17/Treg cells ratio were significantly decreased and the percentage of Treg cells increased in both groups(P<0.05).After treatment,the percentage of IL-17 cells and IL-17/TGF-β1 ratio were both lower in treatment group than that in control group,but the percentage of TGF-β1 cells were higher than that in control group(P<0.01).Conclusion Xiaoqinglong Particles can effectively regulating the Th17/Treg unbalance of asthma patients,and has appropriate value for therapy for asthma and regulating the immunity.