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| HPLC法测定酒石酸美托洛尔骨架缓释片的含量 | |
| 引用本文： | 谢虹虹,刘杰,黄哲丹. HPLC法测定酒石酸美托洛尔骨架缓释片的含量[J]. 中国现代药物应用, 2009, 3(17): 31-32 |
| 作者姓名： | 谢虹虹 刘杰 黄哲丹 |
| 作者单位： | 中山大学附属第三医院,广州,510630 |
| 摘 要： | 目的建立高效液相色谱法测定酒石酸美托洛尔骨架缓释片的含量。方法以十八烷基硅烷键合硅胶为填充剂，乙腈-水-三乙胺-磷酸（115：385：1．6：0．5）为流动相，流速为1．0ml／min，检测波长：274nm。结果酒石酸美托洛尔在25—250μg/ml线性关系良好，r=0．9999，平均回收率99．97％（n=6），RSD=1．81％。结论本法操作简便，结果准确，可用于测定酒石酸美托洛尔骨架缓释片的含量。 |
| 关 键 词： | 骨架缓释片 酒石酸美托洛尔 高效液相色谱法 |
Determination of Metoprolol tartrate sustained-release matrix tablets by HPLC |
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| Affiliation: | XIE Hong-hong,LIU Jie. (The Third Affiliated Hospital,Sun Yat-sen University, Guangzhou , Guangdong 510630,China) |
| Abstract: | Objective To establish a HPLC method for determination of Metoprolol tartrate （MT）sustained-release matrix tablets. Methods The assay was conducted on a ODS Hypersil column with acetontril-water-triethylamine-phosphate（ 115 ： 385 ： 1.6 ： 0. 5 ） as mobile phase. Flow rate was 1.0 ml/min. The detection wavelength was 274 nm. Results The calibration curve is linear over the range of 25 - 250 μg/ml （ r = 0. 9999） for MT. The average recovery was 99. 97% with RSD = 1.81% （n = 6）. Conclusion This method is convenient and accurate which may be used for determination of MT sustained-release matrix tablets. |
| Keywords: | Sustained-release matrix tablets Metoprolol tartrate HPLC |
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