Carnitine and glucuronic acid conjugates of pivalic acid |
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Abstract: | 1. The 1-14C]pivaloyloxyethyl ester of methyldopa administered to man and cynomolgus monkeys resulted in the elimination in the urine of 14C-pivalic acid metabolites.2. Pivaloyl glucuronide and pivaloyl carnitine were identified as the major radioactive urinary metabolites in monkey urine and human urine, respectively.3. N.m.r. analysis indicated that pivaloyl carnitine had a cyclic structure.4. Although the role of carnitine is in the transport of fatty acids across mitochondrial membranes, it may also function in the conjugation of carboxylic acid xenobiotics in humans. |
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