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Anterior clear spaces in keratoconus
Authors:M B Shapiro  M M Rodrigues  M R Mandel  J H Krachmer
Affiliation:2. The Laboratory of Ophthalmic Pathology, National Institutes of Health, Bethesda.;1. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;2. UCSF Department of Ophthalmology, San Francisco, CA, USA;3. Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA;1. Vissum Corporación, Alicante, Spain;2. Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain;3. Ophthalmology Department, Faculty of Medicine, Minia University, Minia, Egypt;4. Ophthalmology Department, AUH, Assiut University, Assiut, Egypt;5. IOBA-Eye Institute, Valladolid, Spain;6. Division of Ophthalmology, University of Valladolid, Valladolid, Spain;1. Sir Charles Gairdner Hospital, Perth, WA, Australia;2. Lions Eye Institute, Perth, WA, Australia;3. Royal Bournemouth Hospital, Bournemouth, United Kingdom;4. Centre for Ophthalmology and Visual Science, University of Western Australia, WA, Australia;1. Servicio de Oftalmología, Hospital Universitario de Cabueñes, Gijón, Asturias, España;2. Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España;1. Laboratory of Food Chemistry and Biochemistry, Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium;2. Puratos, Industrialaan 25, B-1702 Groot-Bijgaarden, Belgium
Abstract:
Anterior clear spaces were observed prospectively at slit-lamp examination in 26 of 69 consecutive eyes (38%) with keratoconus. Two corneal buttons with this finding were examined by light and electron microscopy and revealed breaks in Bowman's layer. Anterior clear spaces should be considered in the spectrum of clinical findings in keratoconus.
Keywords:anterior clear spaces  Bowman's layer  keratoconus
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