| 阿霉素磁性壳聚糖微球的制备及释放实验 |
| |
| 引用本文： | 韩涛,肖清平,张渊明.阿霉素磁性壳聚糖微球的制备及释放实验[J].生物医学工程学杂志,2010(1). |
| |
| 作者姓名： | 韩涛 肖清平 张渊明 |
| |
| 作者单位： | 重庆文理学院化学系;重庆市第二人民医院普外科;暨南大学化学系; |
| |
| 基金项目： | 广东省自然科学基金资助项目(04006966); 广东省卫生科研基金资助项目(A2003697) |
| |
| 摘 要： | 应用改进的悬浮交联技术制备磁性壳聚糖(chitosan,CS)纳米微球。结果显示:该药物微球基本呈球形,其粒径在200~800 nm之间,并且显示了好的磁响应性。阿霉素(doxorubicin,DOX)为试验药物,DOX和CS以化学键(-N=C-)结合在一起,药物含量在1%~15%(w/w)。pH值的大小对其药物体外释放试验的影响很大,当pH为1、2和4时,7 d内药物的释放从22.0%、13.4%降至4.1%。该微球为pH敏感的磁靶向药物微球。
|
| 关 键 词： | 纳米粒子 乳液 磁性药物靶向 药物载体 |
Preparation and Release Exam of Magnetic Chitosan Nano-spheres of Doxorubicin |
| |
| Han Tao Xiao Qingping Zhang Yuanming.Preparation and Release Exam of Magnetic Chitosan Nano-spheres of Doxorubicin[J].Journal of Biomedical Engineering,2010(1). |
| |
| Authors: | Han Tao Xiao Qingping Zhang Yuanming |
| |
| Institution: | Han Tao1 Xiao Qingping2 Zhang Yuanming31(Department of Chemistry,Chongqing University of Arts , Sciences,Chongqing 402160,China)2(Department of General Surgery,the Second People\'s Hospital of Chongqing,China)3(Department of Chemistry,Jinan University,Guangzhou 510632,China) |
| |
| Abstract: | Magnetic chitosan(CS) nano-spheres were prepared by the modified suspension cross-linking technique.The results demonstrated that the magnetic drug nano-spheres are mainly spherical in form with a size of 200 to 800 nm,and show good magnetic responsivity.Here,Doxorubicin was used as exam drug.Glutaraldehyde connects Doxorubicin to CS by the chemical bond(-N=C-), and the drug content is in range of 1% to 15%(w/w).The chemical bond is broken depending on pH,so pH is the important factor for the release of dox... |
| |
| Keywords: | Nano-particle Emulsion Magnetic drug targeting Drug carrier |
| 本文献已被 CNKI 等数据库收录！ |
|
