Activity of Clarithromycin or Rifampin Alone or in Combination against Experimental Rhodococcus equi Infection in Mice |
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| Authors: | Alexandra J. Burton Steeve Giguère Londa J. Berghaus Mary K. Hondalus |
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| Affiliation: | aDepartment of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA;bDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA |
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| Abstract: | ![]()
Treatment of mice with the combination of clarithromycin with rifampin resulted in a significantly lower number of Rhodococcus equi CFU in the organs of mice than treatment with either drug alone or placebo. There was no significant difference in the number of R. equi CFU between mice treated with clarithromycin monotherapy, rifampin monotherapy, or placebo. The combination of clarithromycin with rifampin conferred a clear advantage over either drug as monotherapy in this model of chronic R. equi infection. |
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