硝苯吡啶与阿屈可林或维库溴铵联用对患者神经肌肉阻滞效应影响的研究

观察了钙通道阻滞药（ＣＣＢ）硝苯吡啶（Ｎｉｆ）与阿屈可林（ＡＴＣ）或维库溴铵（ＶＣＲ）联用对患者神经肌肉阻滞（ＮＭＢ）效应的影响。２０ 例用Ｎｉｆ 治疗者随机分成两组（ＡＮ和ＶＮ组）；２０ 例未用Ｎｉｆ患者亦随机分成两个对照组（ＡＣ和 ＶＣ组）；ＡＮ和 ＶＮ组患者Ｎｉｆ的剂量分别为 ０.４１±０．０１ｍｇ／ｋｇ和０．２２±０．０１ｍｇ／ｋｇ。结果表明；用Ｎｉｆ（１０～３０ｍｇ）患者血清Ｃａ２＋从３０分钟开始下降，一直持续至１８０分钟，尤以 ６０～９０分钟时下降更明显（Ｐ<０．０５）。 ＡＮ组和ＶＮ组患者肌松起效、高峰出现时间有缩短趋势，但与对照组（ＡＣ和ＶＣ组）相比无统计学差异；无反应期、高峰持续、肌松维持、２５％恢复时间相似（Ｐ＞０.０５）；提示：Ｎｉｆ常用剂量对ＡＴＣ、ＶＣＲ的肌松效应影响较小，无明显增强患者ＮＭＢ之作用。

Effects of neuromuscular blocking action of a- tracurium and vecuronium in patients on nifedipine therapy.

Effects of neuromuscular blocker (NMB) of atracurium (ATC) and vecuronium (VCR ) in patients on calcium - channel blocker(CCB), nifedipine, therapy were studied with Accelograph. Twenty patients on nifedipine therapy were randomly allocated to two groups (AN and VN). Twenty patients with no nifedipine were randomly divided into two groups (AC and VC),as control. The doses of nifedipine in groups AN and VN were 0. 41 10. 01mg.kg-1 and 0. 22 0. 01mg .kg-1 respectively. The results showed that plasma levels of Ca2 in patients were decreased progressively from 30 to 180 minutes after oral nifedipine (10 - 30mg). The reduced rate of Ca2 in group CCB was more obvious than those of control group in 60 - 90 minutes (P<0. 05). The time of onset and time of peak relaxation in groups AN and VN were shortened as compared with the controlled groups AC and VC,but statistically not significante. The time of non-response,time of continuous peak relaxation and the duration of 25% recovery were similar in groups AN and AC, groups AN and VC (P>0. 05). It is suggested that NMB effects of ATC and VCR in patients by CCB, nifedipine, were insignificance, and the action of NMB in Chinese.