| 南极海茸多糖咀嚼片的制备及含量测定 |
| |
| 引用本文： | 李建杰,胡婷,李全才,杨程,路晓,丛大鹏,赵峡,于广利.南极海茸多糖咀嚼片的制备及含量测定[J].中国海洋药物,2019,38(1):56-62. |
| |
| 作者姓名： | 李建杰 胡婷 李全才 杨程 路晓 丛大鹏 赵峡 于广利 |
| |
| 作者单位： | 中国海洋大学医药学院,中国海洋大学医药学院,中国海洋大学医药学院,青岛海洋生物医药研究院股份有限公司,中国海洋大学医药学院,青岛海洋生物医药研究院股份有限公司,中国海洋大学医药学院,中国海洋大学医药学院 |
| |
| 基金项目： | 青岛市海洋生物医药科技创新中心建设专项(2017-CXZX01-3-13)；国家自然科学基金委/山东省政府联合基金（U1606403）；青岛海洋科学与技术国家实验室鳌山科技创新计划（No.2015ASKJ02） |
| |
| 摘 要： | 目的：研制南极海茸多糖咀嚼片的配方工艺,并建立含量测定方法。方法：以南极海茸多糖为原料,采用湿法制粒压片工艺,通过正交实验,以多指标综合评分法,确定最适工艺配方。采用Gibbons 比色法测定咀嚼片中南极海茸多糖的含量。结果：南极海茸多糖咀嚼片的优选处方为：南极海茸多糖10%,填充剂木糖醇、甘露醇和山梨醇78%,风味剂11.5%,硬脂酸镁0.5%。采用Gibbons 比色法,检测到咀嚼片中岩藻糖含量为5.9 mg/g,岩藻糖在10-100 μg范围内线性关系良好(r=0.9993),回收率在95.8%-103.3%之间, RSD=1.88%(n=6)。结论：按照正交优化的配方工艺,可制备出性状良好、口感酥脆、风味协调且具有海洋特色的南极海茸多糖咀嚼片。Gibbons 比色法检测结果准确,操作简单快速,可用于南极海茸多糖嚼片的质量控制。
|
| 关 键 词： | 南极海茸多糖 咀嚼片 Gibbons 比色法 岩藻糖 |
| 收稿时间： | 2018/9/3 0:00:00 |
| 修稿时间： | 2018/10/24 0:00:00 |
Preparation and determination of Durvillaea Antarctica polysaccharides chewable tablets |
| |
| LI Jian-jie,HU Ting,Li Quan-cai,Yang Cheng,Lu Xiao,Cong Da-peng,Zhao Xia and Yu Guang-li.Preparation and determination of Durvillaea Antarctica polysaccharides chewable tablets[J].Chinese Journal of Marine Drugs,2019,38(1):56-62. |
| |
| Authors: | LI Jian-jie HU Ting Li Quan-cai Yang Cheng Lu Xiao Cong Da-peng Zhao Xia and Yu Guang-li |
| |
| Institution: | School of Medicine and Pharmacy,Ocean University of China,Shan dong Provincial key Laboratory of Glycoscience and Glycoengineering,Marine Biomedical Research Institute of Qingdao Co,Ltd,School of Medicine and Pharmacy,Ocean University of China,Shan dong Provincial key Laboratory of Glycoscience and Glycoengineering,Marine Biomedical Research Institute of Qingdao Co,Ltd,School of Medicine and Pharmacy,Ocean University of China,Shan dong Provincial key Laboratory of Glycoscience and Glycoengineering,Marine Biomedical Research Institute of Qingdao Co,Ltd,,School of Medicine and Pharmacy,Ocean University of China,Shan dong Provincial key Laboratory of Glycoscience and Glycoengineering,Marine Biomedical Research Institute of Qingdao Co,Ltd,,School of Medicine and Pharmacy,Ocean University of China,Shan dong Provincial key Laboratory of Glycoscience and Glycoengineering,Marine Biomedical Research Institute of Qingdao Co,Ltd,School of Medicine and Pharmacy,Ocean University of China,Shan dong Provincial key Laboratory of Glycoscience and Glycoengineering,Marine Biomedical Research Institute of Qingdao Co,Ltd |
| |
| Abstract: | |
| |
| Keywords: | Durvillaea Antarctica polysaccharides Chewable tablets Gibbons colorimetric method Fucose |
|
| 点击此处可从《中国海洋药物》浏览原始摘要信息 |
| 点击此处可从《中国海洋药物》下载免费的PDF全文 |
|
