孟鲁司特钠致儿童不良反应文献分析

目的：分析孟鲁司特钠致儿童药物不良反应（ADR）的特点，为临床合理用药提供指导。方法：检索中国期刊全文数据库（CNKI）、万方数据库、PubMed数据库关于孟鲁司特钠致儿童ADR病例，从发生ADR患儿的性别、年龄、发生时间、转归、临床表现、累及器官-系统等方面进行分析。结果：收集到符合条件的文献15篇，共19例患儿；ADR男性患儿发生率（68.42%）明显高于女性（31.58%），不良反应多发生在用药后1周内（63.16%），2~5岁儿童ADR发生率最高（36.84%）；累及系统-器官以精神系统（63.16%）和消化系统（10.53%）为主，主要临床表现为睡眠障碍、注意力不集中、攻击性行为、肝功能异常等。结论：使用孟鲁司特钠时应加强监测，以减少ADR的发生。

Literature Analysis of Pediatric Adverse Drug Reactions Induced by Montelukast Sodium

Objective: To investigate the characteristics of pediatric adverse drug reactions (ADR) induced by montelukast, and to provide reference for rational clinical drug use. Methods: CNKI, Wanfang database and PubMed were retrieved to collect the pediatric ADR induced by montelukast, and statistical analysis was conducted on gender, age, occurrence time, prognosis, clinical manifestations and involved organs-systems. Results: Totally 15 eligible literature were collected, including 19 children. The incidence of ADR in male children was significantly higher (68.42%) than that in female children (31.58%), and most of the ADR occurred within 1 week after administration (63.16%). The incidence of ADR in children aged from 2 to 5 years was the highest (36.84%). The system-organs involved by ADR were mainly nervous system (63.16%) and digestive system (10.53%). The clinical manifestations mainly performed as sleep disorders, inattention, aggressive behavior and abnormal liver function, etc. Conclusion: Monitoring should be strengthened to reduce the incidence of ADR when montelustra sodium is used.