Supersuppressive “petite” mutants of yeast |
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Authors: | Regina Goursot Miklos de Zamaroczy Giuseppe Baldacci Giorgio Bernardi |
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Affiliation: | (1) Laboratoire de Génétique Moléculaire, Institut de Recherche en Biologie Moléculaire, 2 PlaceJussieu, F-75005 Paris, France |
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Abstract: | Summary A class of suppressive petite mutants of S. cerevisiae, called here supersuppressive, is characterized by a) the fact that their unmodified mitochondrial genomes are the only ones found in the progeny of crosses with wild-type cells; b) very short repeat units (400–900 base pairs) in their mitochondrial genomes. The repeat units of the three supersuppressive petites investigated here share a common 83 nucleotide sequence, which seems to correspond to an initiation site of DNA replication; the multiple copies of this site in the mitochondrial genomes of supersuppressive petites might explain why these genomes can compete out those of wild-type cells. |
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Keywords: | MitDNA restriction analysis Nucleotide sequences Possible initiation site of DNA replication |
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