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Supersuppressive “petite” mutants of yeast
Authors:Regina Goursot  Miklos de Zamaroczy  Giuseppe Baldacci  Giorgio Bernardi
Affiliation:(1) Laboratoire de Génétique Moléculaire, Institut de Recherche en Biologie Moléculaire, 2 PlaceJussieu, F-75005 Paris, France
Abstract:Summary A class of suppressive ldquopetiterdquo mutants of S. cerevisiae, called here supersuppressive, is characterized by a) the fact that their unmodified mitochondrial genomes are the only ones found in the progeny of crosses with wild-type cells; b) very short repeat units (400–900 base pairs) in their mitochondrial genomes. The repeat units of the three supersuppressive ldquopetitesrdquo investigated here share a common 83 nucleotide sequence, which seems to correspond to an initiation site of DNA replication; the multiple copies of this site in the mitochondrial genomes of supersuppressive ldquopetitesrdquo might explain why these genomes can compete out those of wild-type cells.
Keywords:MitDNA restriction analysis  Nucleotide sequences  Possible initiation site of DNA replication
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