大骨节病病毒病因研究补遗

有关大骨节病(Kaschin-Beck disease,KBD)的病因问题至今仍有争论,本文对以往发表的文章添加必要的补充。以KBD病儿外周血白细胞的病变与KBD剖检病例软骨细胞和骨髓血细胞的病变对照比较。结果清晰地显示该3类细胞呈现完全相同的病变过程:胞核内出现由少到多、由小到大的嗜酸性包涵体,伴随以染色质被溶解破坏反比例地减少耗尽,最终细胞坏死、整个核形成一个嗜酸性包涵体的红色大团块。本文认为:隶属KBD的3类细胞的同一模式坏死,应是两次电镜所见的同一病毒所引起;KBD的本质应是该病毒引起的全身性传染病,软骨病变仅是其全身病变的一部分。

Some supplements to study on viral cause of Kaschin-Beck disease

The cause of Kaschin-Beck disease(KBD)is still controversial.In this paper,some necessary supplements were added to previous articles by the authors The lesions of peripheral blood leukocytes in children with KBD were compared to the lesions of chondrocytes and bone marrow blood cells in autopsy cases of KBD.By comparison,it can be clearly seen that the three types of cells showed exactly the same pathological process:eosinophilic inclusion bodies appeared in the nucleus from less to more,from small to large,accompanied by the chromatin being dissolved and destroyed,and finally,the cell died and the entire nucleus formed an eosinophilic inclusion body in large red clump.This article believes that the same pattern of necrosis of the three types of cells of KBD should be caused by the same virus seen twice in electron microscopy.The essence of KBD should be that the systemic infectious diseases caused by the virus,and its cartilage lesions are only part of the systemic lesions.