| 低频超声透皮给药的研究进展与应用 |
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| 引用本文： | 屠熙,尹芹芹,张文胜,黄华.低频超声透皮给药的研究进展与应用[J].生物医学工程学杂志,2008,25(6). |
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| 作者姓名： | 屠熙 尹芹芹 张文胜 黄华 |
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| 作者单位： | 1. 四川大学,电气信息学院,医学信息工程系,成都,610065
2. 四川大学,华西医院,麻醉与危重急救研究室,成都,610041 |
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| 摘 要： | 低频超声可以增强包括大分子药物在内的许多药物的透皮传输,其主要机制是超声的空化作用,大多数人认为是通过改变角质层角化细胞排列结构来提高皮肤渗透能力的.低频超声透皮给药已被人们用于离体实验和动物活体实验,到目前为止,无论是小分子透皮传输还是大分子透皮传输都有很多成功的例子.但是真正通过低频超声透皮导入药物进行治疗的临床应用报道很少,需要更进一步大量的临床试验以确定其安全性与实用价值.一旦其安全性得以证实,合适的低频超声透皮仪研制成功,低频超声快速透皮必将成为一种安全、有效、可控、经济的新型给药方式.
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| 关 键 词： | 低频超声 超声导入 空化作用 增透效应 |
The Progress of Research on Low-frequency Sonophoresis and Its Applications |
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| Tu Xi,Yin Qinqin,Zhang Wensheng,Huang Hua.The Progress of Research on Low-frequency Sonophoresis and Its Applications[J].Journal of Biomedical Engineering,2008,25(6). |
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| Authors: | Tu Xi Yin Qinqin Zhang Wensheng Huang Hua |
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| Institution: | School of Medical Information Engineering;College of Electrical Engineering and Information;Sichuan University;Chengdu 610065;China;Laboratory of Anesthesia & Critical Care Medicine;West China Hospital;Chengdu 610041;China |
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| Abstract: | Low-frequency ultrasound can increase the transdermal delivery of many drugs,including macromolecular drugs.The main mechanism is ultrasonic cavitation.Most researchers pointed out that it could change the form-structure of stratum corneum keratinocytes and,in this way,it can improve the permeability of skin.Low-frequency sonophoresis has been in use for in-vitro experiments and in-vivo animal experiments,and so far,both small-molecules transdermal delivery and macromolecules transdermal delivery have been ... |
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| Keywords: | Low-frequency ultrasound Sonophoresis Cavitation Transdermal enhancement |
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