阿托伐他汀对兔动脉粥样硬化模型血管壁炎症的影响

目的　探讨阿托伐他汀对血管壁炎症的影响。方法　将 2 9只新西兰白兔随机分为正常组 (n=7)、模型组 (n=7)、用药 5周组 (n=7)及用药 9周组 (n=8)。实验前后分别抽血测 C反应蛋白 (CRP) ,采用兔抗人抗胰蛋白酶(AAT)多克隆抗体标记血管内膜炎症细胞。结果　用药 9周组、用药 5周组与正常组相比 ,血 CRP水平明显降低 ,用药 9周组与模型组相比 ,内膜 AAT阳性指数减少。结论　阿托伐他汀具有抑制粥样硬化血管壁炎症的作用

Effect of atorvastatin on vascular inflammation in an atherosclerotic rabbit model

Objective To investigate the effect of atorvastatin on vascular inflammation. Methods 29 healthy New Zealand white rabbits were randomly divited into 4 groups:normal group( n =7),pathological group( n =7), 5 week atorvastatin treatment group( n =7)(2.5mg/kg/d) and 9 week atorvastatin treatment group( n =8)(2.5mg/kg/d).At the onset and the end of the study ,fasting blood samples were collected for C reactive protein(CRP) assay,the injuried ilial arteries were processed for immunohistochemical analysis,polyclonal antibodies for AAT were used to identify the inflammatory cells in the vascular walls. Results In 9 week treatment group and 5 week treatment group compared with pathological group serum CRP level was remarkably reduced, in 9 week treatment group compared with pathological group the number of inflammatory cells in intima was decreased. Conclusions Atorvastatin can inhibit vascular inflammation.