川崎病丙种球蛋白耐药及冠状动脉损伤早期预测指标的研究进展

川崎病是急性全身性血管炎综合征,主要影响冠状动脉.该病的长期预后取决于冠状动脉病变程度.早期应用大剂量静脉丙种球蛋白可以减少冠状动脉病变,丙种球蛋白耐药者冠状动脉病变风险大,早期预测丙种球蛋白耐药及冠脉损伤、及时采取措施对改善预后意义重大.该文对川崎病丙种球蛋白耐药及冠状动脉损伤的预测指标作一介绍.

Predictors for intravenous immunoglobulin resistance and coronary artery leisions in Kawasaki disease

Kawasaki disease（KD） is an acute,systemic vasculitis syndrome that primarily affects coronary arteries.The long-term prognosis depends on the severity of coronary artery leisions（CAL）.Treatment with high-dose intravenous immunoglobulin（IVIG） within 10 days of the onset of fever is proven to decrease the incidence of CAL.Patients with IVIG resistance is at a high risk to be affected by CAL.How to predict IVIG resistance and CAL in the early stage is helpful for improving the outcome of Kawasaki disease.Thus,predictors of IVIG resistance and CAL for KD were reviewed in this article.