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Post-transplant lymphoproliferative disorder after solid-organ transplant in children
Affiliation:1. Associate Professor of Surgery, University Of Cincinnati;2. Ryckman Chair of Pediatric Surgery, Professor of Surgery;2. Bristol Eye Hospital, Bristol, United Kingdom;3. Department of Histopathology, Southmead Hospital, Bristol, United Kingdom;1. Brigham and Women’s Hospital Heart and Vascular Center, and Harvard Medical School, Boston, Massachusetts;2. Department of Health Policy, London School of Economics and Political Science, London, United Kingdom;3. Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, Utah;1. Department of Petroleum Engineering, Kazan Federal University, Kazan 420008, Russia;2. Department of Physical Chemistry, Kazan Federal University, Kazan 420008, Russia;3. Institute of Geology and Petroleum Technologies, Kazan Federal University, Kazan 420008, Russia;4. A.P. Krylov All-Russian Oil and Gas Research Institute Moscow, 127422, Russia;5. Zarubezhneft Oil Company, Moscow 101000, Russia;1. Division of Pediatric Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD;2. Center for Outcomes Research, Johns Hopkins University School of Medicine, Baltimore, MD;3. Division of Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD
Abstract:
The post-transplant lymphoproliferative disorders (PTLD) are a diverse group of potentially life-threatening conditions affecting organ transplant recipients. PTLD arises in the setting of an attenuated host immunologic system that is manipulated to allow a foreign graft but then fails to provide adequate immune surveillance of transformed malignant or premalignant lymphocytes. The diversity of biological behavior and clinical presentation makes for a challenging clinical situation for those involved in the care of children with PTLD occurring after solid-organ transplantation. This review details a large transplant center’s multidisciplinary approach to monitoring for PTLD and systematic approach to intervention, which has been essential for early recognition and successful treatment.
Keywords:PTLD  Post-transplant lymphoproliferative disorder
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