2008-2017年佛山市无偿献血人群梅毒流行趋势分析

目的:了解佛山市无偿献血人群的梅毒感染流行情况,为完善输血安全措施提供参考依据。方法:选取2008-2017年佛山市无偿献血者657 382例,对其血液标本进行梅毒螺旋体(treponema pallidum,TP)抗体检测,并对TP抗体阳性的检出情况及流行病学资料进行统计学分析。采用ELISA法对梅毒抗体筛查检测,对初检结果阳性者进一步采用梅毒螺旋体血凝试验(TPHA)进行确认。结果:2008年1月至2017年12月佛山市无偿献血人群(657 382人)共检测出梅毒螺旋体抗体阳性者2 502例,总阳性率为0.38%,2008-2017年的梅毒螺旋体抗体阳性率分别为0.43%、0.40%、0.41%、0.43%、0.50%、0.32%、0.36%、0.32%、0.37%和0.32%,抗体阳性率呈逐渐下降的态势(P

Trend of Syphilis Infection among Voluntary Blood Donors in Foshan City from 2008 to 2017

Objective:To investigate the prevalence of syphilis infection in voluntary blood donors in Foshan City,so as to provide reference for improving the infusion blood safety strategy of city.Methods:A total of 657382 voluntary blood donors in Foshan City from January 2008 to December 2017 were selected.The blood samples were tested for treponema pallidum.The prevalence trends,the detection rate of treponema pallidum infection and epidemiological data were statistically analyzed.Enzyme-linked immunosorbent assay(ELISA)was performed for antibody screening in blood samples.The two-hole retest was then performed for the samples which were positive in initial test,meanwhile,they were also confirmed by the treponema hemagglutination blood coagulation test(TPHA).Results:First,the annual infection rate of treponema pallidum in Foshan City from January 2008 to December 2017 was 0.43%,0.40%,0.41%,0.43%,0.50%,0.32%,0.36%,0.32%,0.37%and 0.32%,respectively.A total of 2502 cases of treponema pallidum infection were detected,the overall infection rate was 0.38%,and the infection rate decreased year by year(x2=23.826,P<0.05).Second,among the 657382 samples of voluntary blood donors,2502 were showed the positive treponema pallidum antibody(0.38%).In 2015-2017,791 donors were showed positive treponema pallidum antibody,676 case out of which were confirmed positive,0.34%with the positive coincidence rate of 85.46%.Third,this group of 676 syphilis infection cases were male-dominated(0.35%,577/164484).The age distribution was 18-53 years old,and the average age was 32 years,among which 35-44 years old accounted for 0.33%(138/41858).The education level of in donors with treponema pallidom positive mainly ranked at low or lower levels under janior college(0.32%,571/180917).The occupation is mainly outside work and company staff(0.39%,452/115101).The marital status is mainly unmarried(0.29%,377/130905).The place of origin is mainly non-local(0.29%,570/198063).Conclusion:The positive rate of treponema pallidum shows a downward trend in 2008-2017.Among the individuals with comfirmed TP antibody positive in 2015-2017,the nonlocal,unmarried and low educated males are main population,moreover more than half of them are migrant worker or company employeers.