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| 红花妊娠毒性选择性表达的实验研究 | |
| 引用本文： | 赵云龙,冯蓓,周宜,张静. 红花妊娠毒性选择性表达的实验研究[J]. 辽宁中医杂志, 2011, 0(11): 2274-2276 |
| 作者姓名： | 赵云龙 冯蓓 周宜 张静 |
| 作者单位： | 成都中医药大学基础医学院; |
| 基金项目： | 国家自然科学基金资助项目(A30701113) |
| 摘 要： | 目的:通过研究红花的毒性作用对不同机能状态下的妊娠大鼠的选择性,探讨中药的毒性作用在机体不同机能状态下具有特异的选择性。方法:用含生药2g/kg的红花煎剂分别给正常妊娠大鼠(红花组)和外伤血瘀妊娠大鼠(红花治疗组)灌胃,观察红花煎液分别对两组大鼠妊娠和胚胎发育的影响。结果:与空白组比较,红花组生产数明显减少(P<0.001),妊娠时间延长(P<0.05),完全流产率高达25%,胚胎未成形率为35%,母体体重增长缓慢(P<0.05),肝重指数及肾重指数均有所增高,胚胎宫内生长迟缓率(IUGR)高达100%;而红花治疗组在妊娠和胎儿的各项指标上均接近于空白组。结论:红花仅对正常孕鼠表现为毒性作用,说明红花的妊娠毒性在机体处于不同机能状态下具有选择性。 |
| 关 键 词： | 红花 妊娠毒性 选择性表达 |
Study on Selective Expression of Toxicity in Pregnant Mice of Flos Carthami |
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| ZHAO Yun-long,FENG Bei,ZHOU Yi,ZHANG Jing. Study on Selective Expression of Toxicity in Pregnant Mice of Flos Carthami[J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 0(11): 2274-2276 | |
| Authors: | ZHAO Yun-long FENG Bei ZHOU Yi ZHANG Jing |
| Affiliation: | ZHAO Yun-long,FENG Bei,ZHOU Yi,ZHANG Jing(Chengdu University of TCM,Chengdu 611137,Sichuan,China) |
| Abstract: | Objective:To discuss the specific selection of toxicity of Chinese materia medica in different functional status of humans by study on selective expression of toxicity in pregnant mice of flos carthami(Honghua,Safflower).Methods:Normal pregnant mice(Honghua group)and pregnant mice with blood stasis(Honghua treated group)were given Honghua apozem containing 2g/kg of crude drug to observe the effect on pregnant and embryo development of the two groups treated with Honghua.Results:Compared with the controlled ... |
| Keywords: | Honghua toxicity of pregnancy selective expression |
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