常规剂量胃肠动力药物对口-结肠转运时间的影响

背景：胃肠传输障碍是发生胃肠道症状的最重要原因之一,目前尚缺乏常用胃肠动力药物改善胃肠传输功能疗效的对比研究。目的：研究常规剂量胃肠动力药物对健康志愿者口-结肠转运时间（OCTT）的影响。方法：采用随机、双盲、拉丁方设计的自身对照研究方案,以乳果糖氢呼气试验检测7名健康志愿者的OCTT。口服乳果糖前30 min分别给予多潘立酮10 mg、莫沙必利5 mg、枸橼酸莫沙必利分散片5 mg（服用乳果糖前15 min给予）、伊托必利50 mg、匹维溴铵50 mg和曲美布汀100 mg,并比较不同药物的OCTT。结果：7名健康志愿者的基线平均OCTT为（112.0±3.2）min,多潘立酮、莫沙必利、枸橼酸莫沙必利分散片、伊托必利、匹维溴铵和曲美布汀的OCTT分别为（96.0±2.4）min、（72.2±2.6）min、（71.4±2.0）min、（105.0±2.6）min、（87.0±3.2）min、（135.0±4.1）min,与基线相比差异均有统计学意义（P〈0.05）。枸橼酸莫沙必利分散片的OCTT显著低于其他胃肠动力药物（P〈0.05）。结论：常规剂量枸橼酸莫沙必利分散片对OCTT的促进作用优于其他胃肠动力药物。

Effects of Conventional Dose of Various Gastrointestinal Motility Medicines on Oral-colon Transit Time

Background: Gastrointestinal transit disorder is one of the most important causative factors of abdominal symptoms.Comparative studies on efficacy of various commonly used gastrointestinal motility medicines on gastrointestinal transit time have not been adequately reported.Aims: To study the effects of conventional dose of various gastrointestinal motility medicines on oral-colon transit time(OCTT) in healthy volunteers.Methods: A randomized,double-blind,Latin square design and self-control study was carried out.OCTT of 7 healthy volunteers was determined by lactulose hydrogen breath test.Domperidone 10 mg,mosapride 5 mg,mosapride citrate dispersible tablet 5 mg(15 minutes before oral administration of lactulose),itopride 50 mg,pinaverium bromide 50 mg and trimebutine 100 mg were given 30 minutes before the administration of lactulose,respectively,and the results of OCTT were compared.Results: The average baseline OCTT of 7 healthy volunteers was(112.0±3.2) min.OCTT after administration of domperidone,mosapride,mosapride citrate dispersible tablet,itopride,pinaverium bromide and trimebutine were(96.0±2.4) min,(72.2±2.6) min,(71.4±2.0) min,(105.0±2.6) min,(87.0±3.2) min and(135.0±4.1) min,respectively.Significant differences were found between the OCTT after administration of various gastrointestinal motility medicines and the baseline value(P<0.05).The OCTT of mosapride citrate dispersible tablet was significantly lower than that of other gastrointestinal motility medicines(P<0.05).Conclusions: The efficacy of conventional dose of mosapride citrate dispersible tablet for OCTT is superior to other gastrointestinal motility medicines.