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Chikungunya virus vaccines: Current strategies and prospects for developing plant-made vaccines |
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| Affiliation: | 1. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran;2. School of Advance Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran;3. Biotechnology Incubator, Shiraz University of Medical Sciences, Shiraz, Iran;4. Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;5. Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;6. Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran;7. Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, Iran |
| Abstract: | Chikungunya virus is an emerging pathogen initially found in East Africa and currently spread into the Indian Ocean Islands, many regions of South East Asia, and in the Americas. No licensed vaccines against this eminent pathogen are available and thus intensive research in this field is a priority. This review presents the current scenario on the developments of Chikungunya virus vaccines and identifies the use of genetic engineered plants to develop attractive vaccines. The possible avenues to develop plant-made vaccines with distinct antigenic designs and expression modalities are identified and discussed considering current trends in the field. |
| Keywords: | Oral vaccine Vaccine cost Transgenic plant Transient expression Transplastomic plant Edible crop E antigen Virus like particles |
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