Concurrent and cross-season protection of inactivated influenza vaccine against A(H1N1)pdm09 illness among young children: 2012–2013 case–control evaluation of influenza vaccine effectiveness |
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| Institution: | 1. Guangzhou Center for Disease Control and Prevention, Guangzhou, China;2. Nanfang Hospital, Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou, China;3. Influenza Division, Centers for Disease Control and Prevention, Atlanta, United States;1. Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Private Bag X05, Onderstepoort 0110, South Africa;2. Department of Microbiology and Plant Pathology, Faculty of Agricultural and Natural Sciences, University of Pretoria, Pretoria 0002, South Africa;3. Department of Veterinary Tropical Diseases, Faculty of Veterinary Science University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa;4. Makerere University, College of Veterinary Medicine, Animal Resources and Biosecurity, PO Box 7062, Kampala, Uganda;1. Hefei Center for Disease Control and Prevention, Anhui, China;2. Department of Biostatistics, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, 200231 Xuhui District, Shanghai, China;3. Shanghai Key Laboratory of Meteorology and Health, Shanghai, China;1. PathWest Laboratory Medicine, Perth, WA, Australia;2. WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, VIC, Australia;3. University of Melbourne, Melbourne, VIC, Australia;4. Department of Health (Western Australia), Perth, WA, Australia;1. Department of Pharmacy, Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), University of Groningen, A. Deusinglaan 1, P.O. Box XB45, 9713AV Groningen, The Netherlands;2. Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, FA40, 9700RB Groningen, The Netherlands;3. Department of Medical Microbiology, Division of Clinical Virology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands;4. Department of Infectious, Chest Diseases, Dermatovenerology and Allergology, Vilnius University, Birutes str. 1, LT-08117 Vilnius, Lithuania;5. Lithuanian University of Health Sciences, Department of Infectious Disease, Kaunas Clinical Hospital, Baltijos str. 120, LT-47116 Kaunas, Lithuania;6. Institute of Public Health, Faculty of Medicine, Vilnius University, Ciurlionio str. 21/27, LT-03101 Vilnius, Lithuania;1. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China;2. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;3. Jiangsu Provincial Center for Disease Control and Prevention, China |
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| Abstract: | In 2012–2013, we examined 1729 laboratory-confirmed A(H1N1)pdm09 influenza cases matched 1:1 with healthy controls and estimated influenza vaccine effectiveness (VE) for trivalent inactivated influenza vaccine (IIV3) to be 67% (95% confidence interval = 58–74%) for ages 8 months to 6 years old. Among children aged 8–35 months old, VE for fully vaccinated children (73%, 60–81%) was significantly higher than VE for partially vaccinated children (55%, 33–70%). Significant cross-season protection from prior IIV3 was noted, including VE of 31% (8–48%) from IIV3 received in 2010–2011 against influenza illness in 2012––2013 without subsequent boosting doses. |
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| Keywords: | A(H1N1)pdm09 influenza Influenza vaccines Vaccine effectiveness Children Prior vaccination |
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