| 解偶联蛋白在脑缺血疾病中的作用研究进展 |
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| 引用本文： | 吴传鸿,李韶菁,杨洪军,陈畅,张宁,李德凤. 解偶联蛋白在脑缺血疾病中的作用研究进展[J]. 中国新药杂志, 2012, 0(6): 623-627,653 |
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| 作者姓名： | 吴传鸿 李韶菁 杨洪军 陈畅 张宁 李德凤 |
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| 作者单位： | 中国中医科学院中药研究所;河北联合大学基础医学部药理学教研室 |
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| 基金项目： | 国家自然科学基金(30901976);中国中医科学院第二批自主选题项目(Z02076,Z02063) |
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| 摘 要： | 解偶联蛋白(uncoupling proteins,UCPs)是一类位于线粒体内膜上的阴离子载体蛋白,属于线粒体载体蛋白超家族。到目前为止,已经发现并确认UCPs同系物为5种,即UCP1～UCP5,中枢神经系统中主要含有UCP2,UCP4和UCP5 3种亚型,已经证实其对于脑缺血后的氧化应激、线粒体膜电势及ATP绝对水平的维持具有重要的作用,本文主要将UCPs在脑缺血疾病中相关作用进行综述,希望可以为脑缺血疾病的治疗提供新的研究思路。
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| 关 键 词： | 解偶联蛋白 中枢神经系统 线粒体 脑缺血 |
Progress in research of uncoupling protein in cerebral ischemia |
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| WU Chuan-hong,LI Shao-jing,YANG Hong-jun,CHEN Chang,ZHANG Ning,LI De-feng. Progress in research of uncoupling protein in cerebral ischemia[J]. Chinese Journal of New Drugs, 2012, 0(6): 623-627,653 |
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| Authors: | WU Chuan-hong LI Shao-jing YANG Hong-jun CHEN Chang ZHANG Ning LI De-feng |
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| Affiliation: | 1(1 Institute of Chinese Materia Medica,China Academy of Chinese Medical Science,Beijing 100700,China; 2 Department of Pharmacology,Department of Foundamental Medical Science, Hebei United University,Tangshan 063000,China) |
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| Abstract: | The uncoupling proteins(UCPs) are a superfamily of mitochondrial anion-carrier proteins that are located on the inner mitochondrial membrane.So far,there are five homologues of UCPs identified.They are UCP1 to UCP5.The UCPs in the central nervous system is mainly composed of three subtypes,UCP2,UCP4 and UCP5.It has been confirmed that they relate to oxidative stress,mitochondrial membrane potential and absolute ATP levels after cerebral ischemia.UCPs provide a new strategy for the treatment of cerebral ischemia.In this paper,we reviewed the physiological function of UCPs and the changes after cerebral ischemia. |
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| Keywords: | uncoupling protein central nervous system mitochondria cerebral ischemia |
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