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| 8-乙酰哈巴苷在大鼠体内组织分布及排泄 | |
| 引用本文： | 刘德文,张毅,王锦玉,李德凤,游云,曹岚,王芳,冯伟红,刘晓谦,陈两绵,仝燕.8-乙酰哈巴苷在大鼠体内组织分布及排泄[J].中国实验方剂学杂志,2011,17(23):220-222. |
| 作者姓名： | 刘德文 张毅 王锦玉 李德凤 游云 曹岚 王芳 冯伟红 刘晓谦 陈两绵 仝燕 |
| 作者单位： | 1. 中国中医科学院中药研究所,北京100700;江西中医学院,南昌330004 2. 中国中医科学院中药研究所,北京,100700 3. 江西中医学院,南昌,330004 |
| 基金项目： | "重大新药创制"科技重大专项 (2009ZX09301-005) |
| 摘 要： | 目的:研究8-乙酰哈巴苷在大鼠体内各组织分布及代谢情况。方法:采用高效液相色谱法测定大鼠尾静脉注射给药后不同时间点各组织及排泄物中8-乙酰哈巴苷的含量,分析药物的分布特征。结果:大鼠注射给药后,心、脾、肺、肾、子宫在给药后10 min质量浓度即达到峰值,其中肾中含量最高;肝脏在给药后30 min质量浓度达峰值;60 min后肝、肺、肾中药物均降至较低水平,心、脾、子宫中基本检测不出;8-乙酰哈巴苷注射给药后通过粪便排泄较少,大部分通过尿液排出。结论:8-乙酰哈巴苷注射途径给药主要以药物原型排出体外。 |
| 关 键 词： | 8-乙酰哈巴苷 注射途径 组织分布 排泄 |
| 收稿时间： | 2011/9/15 0:00:00 |
Tissue Distribution and Excretion of 8-Acetylharpagide in Rats |
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| LIU De-wen,ZHANG Yi,WANG Jin-yu,LI De-feng,YOU Yun,CAO Lan,WANG Fang,FENG Wei-hong,LIU Xiao-qian,CHEN Liang-mian and TONG Yan.Tissue Distribution and Excretion of 8-Acetylharpagide in Rats[J].China Journal of Experimental Traditional Medical Formulae,2011,17(23):220-222. | |
| Authors: | LIU De-wen ZHANG Yi WANG Jin-yu LI De-feng YOU Yun CAO Lan WANG Fang FENG Wei-hong LIU Xiao-qian CHEN Liang-mian and TONG Yan |
| Institution: | Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China; Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Traditional Medical Sciences, Beijing 100700, China |
| Abstract: | Objective: To study on tissue distribution and metabolism of 8-acetylharpagide in rats. Method: The content of 8-acetylharpagide in tissue and excreta at different time points after tail vein injection were determined by HPLC, then analyzed distribution of 8-acetylharpagide. Result: After injected, the content of 8-acetylharpagide in heart, spleen, lung, kidney and uterus reached peak in 10 min, the highest concentration was in kidney; Concentration of 8-acetylharpagide in liver reached peak in 30 min, the content of 8-acetylharpagide in liver, lung and kidney reduced to a lower level in 60 min, it could not be detected in heart, spleen and uterus; after injected, 8-acetylharpagide was discharged mostly through urine, less excreted by stool. Conclusion: By injection, 8-acetylharpagide excreted in prototype drugs mainly. |
| Keywords: | 8-acetylharpagide injection means tissue distribution excretion |
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