电纺纳米纤维可降解输尿管支架肌肉埋植的降解性能

背景:作者前期研究了电纺纳米纤维聚乳酸-羟基乙酸共聚物可降解输尿管支架材料的体外降解性能,发现80/20聚乳酸-羟基乙酸共聚物电纺纳米纤维材料在尿液中的降解时间可以满足临床需要。目的:观察80/20聚乳酸-羟基乙酸共聚物电纺纳米纤维输尿管支架的肌肉埋植降解性能。方法:采用静电纺丝法制备80/20聚乳酸-羟基乙酸共聚物纳米纤维输尿管支架,观察其在家兔脊柱旁肌肉中的降解情况。结果与结论:成功制备了电纺纳米纤维输尿管支架,扫描电镜见微观形貌良好。80/20的聚乳酸-羟基乙酸共聚物纳米纤维输尿管支架在体内降解至10周时,支架管降解至初始质量的60%左右,支架出现断裂和崩解,虽降解速度较体外降解稍慢,但其降解性能仍能够满足临床对可降解输尿管支架的需要。

Degradation of biodegradable ureteral stent composed of electrospun nanofibers implanted into the muscle

BACKGROUND: The author has completed the preliminary investigation on degradation of electrospun nanofiber poly lactic acid- glycolic acid copolymer (PLGA) biodegradable ureteral stent material in vitro and found the degradation time of 80/20 PLGA material in urine could meet the clinical needs. OBJECTIVE: To investigate the degradation properties of 80/20 PLGA electrospun nanofiber ureteral stents implanted in muscle. METHODS: The 80/20 PLGA electrospun nanofiber ureteral stents were prepared by electrostatic spinning. The degradation properties of the stents in rabbit paravertebral muscle were observed. RESULTS AND CONCLUSION: Electrospun nanofiber ureteral stents were successfully prepared with a good morphology under scanning electron microscopy. At 10 weeks of degradation of 80/20 PLGA electrospun nanofiber ureteral stents, their mass was 60% of initial mass, and fracture and disintegration of the stents could be seen. Degradation rate of the stents was slightly decreased than that in vitro, but they were still able to meet the clinical needs of biodegradable ureteral stents.