| 双氯芬酸钠栓溶出度测定方法的研究 |
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| 引用本文： | 徐楚鸿,吕永宁,王虎. 双氯芬酸钠栓溶出度测定方法的研究[J]. 中国药房, 2001, 12(7): 427-428 |
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| 作者姓名： | 徐楚鸿 吕永宁 王虎 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院药剂科 |
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| 摘 要： | 目的 :建立双氯芬酸钠栓溶出度测定方法。方法 :比较转篮法和桨法 ,用一阶导数分光光度法检测 ,提取参数 (T50、Td、m ) ,并对参数进行相关性检验。结果 :两种方法溶出参数差异显著 ,桨法优于转篮法。结论 :本试验方法可用于产品质量控制 ,质控标准为45min溶出量不少于标示量的80 %。
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| 关 键 词： | 双氯芬酸钠栓 溶出度测定 一阶导数分光光度法 |
| 文章编号： | 1001-0408(2001)07-0427-02 |
| 修稿时间： | 2000-11-28 |
Study on Dissolution Test Methods for Diclofenac Sodium Suppository |
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| XU Chuhong,LU Yongning,WANG Hu. Study on Dissolution Test Methods for Diclofenac Sodium Suppository[J]. China Pharmacy, 2001, 12(7): 427-428 |
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| Authors: | XU Chuhong LU Yongning WANG Hu |
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| Abstract: | OBJECTIVE:To establish a good method for determining the dissolution rates of diclofenac sodium suppository METHODS:The dissolution method Ⅰ and Ⅱ of ChP(2000) were compared,the first derivative spectrophotometry was used and the parameters(T50,Td,m) obtained from these samples were brought for correlation analysis RESULTS:The dissolution rate of diclofenac sodium suppository from the dissolution method Ⅰ and Ⅱ were remarkably different,and the dissolution method Ⅱ was better than Ⅰ CONCLUSION:The method established by this study is suitable for the quality control of diclofenac sodium suppository,and the percentage of dissolution of diclofenac sodium suppository in 45min more than 80% is the standard of quality control |
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| Keywords: | diclofenac sodium suppository dissolution first derivative spectrophotometry |
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