| 含烟酸高分子药物微球的合成研究 |
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| 引用本文： | 孙玉,李庆海,汪凌云,沈良骏. 含烟酸高分子药物微球的合成研究[J]. 中国药物化学杂志, 2003, 13(5): 273-275 |
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| 作者姓名： | 孙玉 李庆海 汪凌云 沈良骏 |
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| 作者单位： | 安徽师范大学化学与材料科学学院,安徽,芜湖,241000 |
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| 基金项目： | 国家自然科学基金项目(29773001)，安徽省教育厅科研基金项目(2002KJ119) |
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| 摘 要： | 目的 合成可提高药物吸收度的含烟酸的高分子纳米微球。方法 通过DCC法和酰氯法将降血脂药物烟酸以酯键连接到甲基丙烯酸-2-羟基乙酯上得到不饱和的含烟酸的单体(MP)化合物，在此基础上用乳液聚合法制备含烟酸的纳米级高分子微球。结果 单体和聚合物的结构均经核磁共振谱确定，微球的粒径及表观形态用透射电子显微镜观测。结论 乳液聚合法是合成含烟酸高分子药物微球的一种行之有效的方法。
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| 关 键 词： | 药物化学 制备 化学合成 烟酸 乳液聚合 纳米微球 |
| 文章编号： | 1005-0108(2003)05-0273-03 |
Synthesis and characterization of polymeric microspheres containing nicotinic acid |
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| SUN Yu,LI Qing-hai,WANG Ling-yun,SHEN Liang-jun. Synthesis and characterization of polymeric microspheres containing nicotinic acid[J]. Chinese Journal of Medicinal Chemistry, 2003, 13(5): 273-275 |
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| Authors: | SUN Yu LI Qing-hai WANG Ling-yun SHEN Liang-jun |
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| Abstract: | Aim To synthesize high medicine-absorbance polymeric nano-microspheres containing nicotinic acid. Method The unsaturated monomer MP was synthesized through the reaction of nicotinic acid and methacrylic acid-2-hydroxyethyl ester by using two different methods(DCC or acyl chloride). Then the nano-microspheres were made from the above compound monomer by using emulsion polymerization. Result The monomer MP and its polymer were characterized by H-NMR. The size and hydrodynamic radius distribution of the nano-microspheres were measured by the transmission electron microscope. Conclusion Polymeric microspheres that contain nicotinic acid can be effectively synthesized by using emulsion polymerization. |
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| Keywords: | medicinal chemistry preparation chemical synthesis nicotinic acid emulsion polymerization nano-microspheres |
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