ACE 基因 I/D 多态性与动脉血栓性脑梗死的关联性研究 |
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作者姓名: | 何深文 李旺英 林南生 刘凯 黄海威 |
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作者单位: | 1.内科二区,广东省佛山市顺德区均安医院, 广东 佛山 5283292.超声科,广东省佛山市顺德区均安医院, 广东 佛山 5283293.中山大学附属第一医院神经科,广东 广州510080 |
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基金项目: | 广东省佛山市卫生局医学科研课题2011498 |
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摘 要: | 目的研究血管紧张素转换酶(ACE)基因I/D多态位点与动脉血栓性脑梗死的关联性及相关机制。方法选取动脉血栓性脑梗死患者112例和年龄、性别匹配的对照组180例,采用PCR-AFLP技术对ACE基因I/D位点进行分型。 结果单因素分析提示病例组收缩压水平(138.1±19.7 mmHg)显著高于对照组(126.6±20.6 mmHg)(t=4.716,P<0.001);病例组舒张压水平(88.9±10.1 mmHg)显著高于对照组(79.9±10.0 mmHg)(t=7.450,P<0.001)。病例组中ACE基因I/D位点D等位基因频率和DD基因型频率分布均显著高于对照组(等位基因:χ2=4.953,P=0.026; 基因型:χ2=6.303,P=0.043)。病例组和对照组中ACE基因I/D位点基因型DD携带者收缩压及舒张压水平显著高于基因型ID及II携带者。 结论ACE基因I/D位点等位基因D可能是汉族人群动脉血栓性脑梗死遗传易感基因。等位基因D可能通过升高个体血压的机制导致动脉血栓性脑梗死发生。
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关 键 词: | 血管紧张素转换酶 基因多态性 血压 动脉血栓性脑梗死 |
收稿时间: | 2015-02-25 |
Association between ACE gene I/D polymorphism and atherothrombotic infarction |
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Authors: | Shenwen HE Wangying LI Nansheng LIN Kai LIU Haiwei HUANG |
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Institution: | 1.Department of Internal Medicine,un-an Hospital, Foshan 528329, China2.Department of Ultrasonic Medicine, Jun-an Hospital, Foshan 528329, China3.Department of Neurology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China |
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Abstract: | Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene I/D polymorphism and atherothrombotic infarction. Methods 112 patients with atherothrombotic infarction and 180 age, sex-matched healthy subjects were recruited. Genotypes were detected by PCR-AFLP. Results Univariate analysis revealed that systolic blood pressure (SBP) levels for patients (138.1 ± 19.7mm Hg) were significantly higher than those for healthy controls (126.6 ± 20.6 mmHg) (t=4.716, P<0.001), and diastolic blood pressure (DBP) levels for patients (88.9±10.1 mmHg) were significantly higher than those for healthy controls (79.9 ± 10.0 mmHg) (t=7.450, P<0.001). Allele D frequency and distribution of frequency for genotype DD of ACE gene I/D polymorphism for patients were significantly higher than those for healthy controls (allele: x2= 4.953, P=0.026; genotype: x2=6.303, P=0.043). In both groups, the SBP and DBP levels for genotype DD were significantly higher than those for genotype ID and II. Conclusion Allele D of ACE gene I/D polymorphism plays a role in elevating blood pressure and may be a major risk factor for atherothrombotic infarction. |
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