肝X受体调节胆固醇代谢研究新进展 *

肝X受体(liver X receptors, LXRs)属孤核受体家族成员，主要在肝脏中大量表达。LXRs作为一种氧化固醇激活的核受体，参与机体胆固醇代谢和转运、脂肪形成、糖原异生和炎症等多种生理活动的调节。随着对结构和功能的不断深入研究，发现LXRs具有调节体内胆固醇代谢的功能，与心血管疾病如脉粥样硬化、高血压、心肌肥厚、心肌纤维化等的发生发展密切关系，已成为近期研究的热点之一，本文就LXRs调节胆固醇代谢的研究进展进行综述。

Research progress of liver X receptor regulating cholesterol metabolism*

Liver X receptors(LXRs) are members of the orphan nuclear receptor family and are mainly expressed in the liver. As an oxysterol-activated nuclear receptor, LXRs participate in the regulation of various physiological activities including metabolism and transport of cholesterol, fat formation, gluconeogenesis, and inflammation, etc. With the continuous study of structure and function, many studies have found that the function of LXRs regulating cholesterol metabolism in vivo is closely related to the occurrence and development of cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and myocardial fibrosis, which has become a hot topic in recent research. This article reviews the advances in the regulation of cholesterol metabolism of LXRs.