高毒力肺炎克雷伯菌耐药机制研究进展

肺炎克雷伯菌（Klebsiella pneumoniae，KP）是院内感染的常见革兰阴性致病菌；20世纪80年代以来，KP的一种新型变异株-高毒力肺炎克雷伯菌（hypervirulent K.pneumoniae，hvKP）不断产生和蔓延，常感染健康宿主并引起严重的侵袭性感染；早期研究认为高毒力与耐药性不会在同一KP出现，但近期已有hvKP相关菌株耐药甚至多药耐药的报道，耐药性和高毒力的结合可能会成为下一个临床即将面临的重要挑战。现就hvKP耐药报道及相关机制研究进行综述和讨论，希望能为预防和控制耐药hvKP在我国的流行和发展以及为进一步对耐药机制进行深入研究提供参考。

Research Progress of Resistance Mechanism of Hypervirulent Klebsiella Pneumoniae

Klebsiella pneumonia (KP) is a common gram negative pathogen of hospital-acquired infections. A new variant of KP called hypervirulent K. pneumoniae (hvKP) has been gradually produced and spread since the 1980s and often infects healthy hosts and causes serious invasive infections. Early studies have suggested that the high virulence and drug resistance of KP did not overlap, but recently there are reports of drug resistance or even multidrug resistance of hvKP-related strains. Combination of drug resistance and high virulence may become the next important challenge encountered in clinical practice. This paper reviews and discusses some hvKP drug resistance reports and related mechanism in order to provide references for the prevention and control of the prevalence and development of drug-resistant hvKP and further research on drug resistance mechanism in China.