基于中西医临床病证特点的银屑病动物模型分析

基于银屑病中西医临床病证特点,根据现有动物模型与银屑病中西医临床病证特点的吻合度,提出银屑病动物模型评价标准,为银屑病动物模型提供相应的完善思路。本文通过列出中西医银屑病的临床表现和诊断标准,符合西医临床诊断标准1项赋值为8. 3%,符合中医临床中主证1项为15%,次证为8%,对现有银屑病动物模型进行评分。结果发现较高吻合度的动物模型有咪喹莫特诱导模型,其成模速率较快,成本低,但停药后随时间的延长,具有可逆性。一般吻合度的模型为普洛萘尔、十二烷基硫酸钠诱导模型,模型制做简单,速率快,但缺乏中医证候的体现。异体移植模型和基因型模型与西医临床吻合度较高,但与中医证候吻合度较低。由于银屑病是一种易复发的慢性、非感染性皮肤病,治病因素较多,已有模型不能较好的模拟临床症状,应利用多因素造模方式,结合银屑病中医证候及外在主要致病因素,建立体现银屑病中西医临床病证特点的病理模型。因此建立同时体现银屑病中西医临床病证特点的动物模型,完善银屑病病证结合动物模型评价标准,是银屑病中医药未来研究的主要任务。

Analysis of Animal Model of Psoriasis Based on Clinical Characteristics of Traditional Chinese Medicine and Western Medicine

Based on the characteristics of clinical symptoms of psoriasis in traditional Chinese and Western medicine, and according to the coincidence between existing animal models and the characteristics of clinical symptoms of psoriasis in traditional Chinese and Western medicine, the evaluation criteria of psoriasis animal models are put forward, which can provide corresponding improvement ideas for psoriasis animal models. By listing the clinical manifestations and diagnostic criteria of psoriasis in traditional Chinese and Western medicine, this paper assesses the existing animal models of psoriasis, which accords with 8.3% of the clinical diagnostic criteria of Western medicine, 15% of the main symptoms and 8% of the secondary symptoms in traditional Chinese medicine. The results showed that imiquimod-induced model was found to be the best animal model with high coincidence. The rate of modeling was faster and the cost was lower, but it was reversible with the prolongation of withdrawal time. Allogeneic transplantation model and genotype model have high coincidence with Western medicine, but low coincidence with traditional Chinese medicine symptoms. Because psoriasis is a chronic, non-infectious skin disease that is prone to recurrence, there are many factors leading to psoriasis.The existing models can not simulate the clinical symptoms well. We should use multi-factor modeling method to establish a pathological model reflecting the characteristics of clinical symptoms of psoriasis in traditional Chinese and Western medicine combined with the main external pathogenic factors of psoriasis. Therefore, it is the main task for the future research of psoriasis traditional Chinese medicine to establish animal models that reflect the clinical characteristics of psoriasis and Western medicine and improve the evaluation criteria of psoriasis combined with syndrome animal models.