肿瘤细胞间黏附性对免疫逃逸的影响

目的研究肿瘤细胞间黏附力改变对人体细胞免疫反馈的影响。方法建立基于网状波茨模型(cellular Potts model,CPM)模型理论的肿瘤生长-细胞免疫反馈模型,并模拟肿瘤细胞的生长过程以及人体细胞免疫反馈系统。观察不同肿瘤间黏附力时肿瘤受免疫系统的影响情况。结果肿瘤细胞间黏附力正常时,肿瘤在免疫系统强度较低时逃逸,在免疫系统强度较高时被消灭。肿瘤细胞间黏附力较低时,肿瘤在免疫系统强度较低时逃逸,免疫系统强度较高时发生震荡,肿瘤无法被消灭。结论较高的肿瘤间黏附性不利于肿瘤逃避免疫系统,降低肿瘤间黏附力的大小能够有效帮助肿瘤逃避免疫系统的杀灭。当肿瘤极度扩散时,免疫系统将无法将肿瘤彻底消灭。

Effects of Intercellular Adhesion of Tumor on Immune Escape

Objective To study the effect of intercellular adhesion of tumor cells on immune response of human body. Methods A tumor growth-cellular immune feedback model was developed based on cellular Potts model (CPM) to simulate the progression of tumor cells and the cellular immune feedback system, and the influence of adhesion between tumor cells on the immune system was analyzed. Results Under the condition of tumor intercellular adhesion with normal intensity, tumor cells could escape when the immune system was weak and be eliminated when the immune system was strong. Under the condition of tumor intercellular adhesion with low intensity, tumor cells could escape when the immune system was weak, while exhibited behavior of oscillation and could not be eliminated when the immune system was strong. Conclusions Higher adhesion between tumor cells inhibited escape of tumor cells from the immune system, while lower adhesion between tumor cells could effectively help the tumor escape killing from the immune system. When the tumor was extremely spread, the immune system could not completely eliminate tumor cells.