Advances in biomarkers of biliary tract cancers |
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| Institution: | 1. Department of Immunology, School of Basic Medical Science, China Medical University, Shenyang 110122, China;2. Department of Ophthalmology, No. 1 Teaching Hospital, China Medical University, Shenyang 110001, China;3. Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang 110016, China;4. Department of Gynecology, No. 1 Teaching Hospital, China Medical University, Shenyang 110001, China;5. Department of Gynecology Oncology, Shengjing Hospital, China Medical University, Shenyang 110016, China;6. Immune Therapeutics, Inc., 37 North Orange Avenue, Suite 607, Orlando, FL 32801, USA |
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| Abstract: | Tumor biomarkers can be applied for early diagnosis or precise treatment, thereby leading to personalized treatment and better outcomes. Biliary tract cancers (BTCs) are a group of cancers that occurs in different locations and have different clinical or genetic properties. Though the incidence of BTCs is rare, BTCs are among the most lethal cancers in the world and all have very low 5-year survivals. Lack of efficient early diagnostic approaches or adjuvant therapies for BTCs are main reasons. These urge us to broaden the researches into BTC biomarkers. Although few progresses of diagnostic biomarkers for BTCs have been achieved, there are still some advances in prognostic, predictive and therapeutic areas. In this review, we will focus on these achievements. |
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| Keywords: | Biomarker Biliary tract cancer Gallbladder cancer Cholangiocarcinoma |
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