| Myc基因家族在喉癌中的异常扩增及其意义 |
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| 引用本文： | 全成实,郭晓峰.Myc基因家族在喉癌中的异常扩增及其意义[J].中华耳鼻咽喉头颈外科杂志,1998(5). |
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| 作者姓名： | 全成实 郭晓峰 |
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| 作者单位： | 白求恩医科大学第一临床学院耳鼻咽喉-头颈外科 |
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| 摘 要： | 目的探讨Ｍｙｃ基因家族在喉癌中的异常扩增及其临床意义。方法应用ＰＣＲ非变性聚丙稀酰胺凝胶电泳激光扫描技术检测了３２例喉癌组织、１２例癌旁组织和６例正常组织。结果正常组织细胞Ｍｙｃ基因无扩增，３２例喉癌中４７％（１５／３２）有Ｃｍｙｃ和Ｌｍｙｃ扩增，４１％（１３／３２）有Ｎｍｙｃ基因扩增。Ｍｙｃ基因扩增率与年龄、性别、喉癌临床分期及分化程度无关（Ｐ＞０．０５），但有淋巴结转移的患者的Ｎｍｙｃ扩增率明显高于无淋巴结转移者（Ｐ＜０．０１）。结论Ｍｙｃ基因３个成员异常扩增是喉癌发生的原因之一，Ｎｍｙｃ扩增在喉癌淋巴结转移过程中可能起正性调控作用。
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| 关 键 词： | 喉肿瘤 基因.Myc 肿瘤转移 扩增 |
Analysis of Myc gene family in laryngeal cancer |
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| Quan Chengshi,Guo Xiaofeng.Analysis of Myc gene family in laryngeal cancer[J].Chinese JOurnal of Otorhinolaryngology Head and Neck Surgery,1998(5). |
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| Authors: | Quan Chengshi Guo Xiaofeng |
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| Institution: | Quan Chengshi,Guo Xiaofeng. Department of Otolaryngology Head and Neck Surgery,First Teaching Hospital,Norman Bethune University of Medical Sciences,Changchun 130021 |
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| Abstract: | Objective To study the abnormal amplification and role of Myc gene family in the development of laryngeal cancer. Method A PCR PAGE Laser scanning technique was applied. Results There was no Myc gene amplification in the nomal laryngeal tissues.The abnormal L myc and C myc gene were positive in 47%(15/32) of laryngeal cancers and 41%(13/32) of the cancers shown the N myc gene amplification.Myc gene amplification was not related to age,sex and differentiation ( P >0.05),but the N myc amplification was higher in patients with lymph node metastesis ( P <0.05). Conclusion The N myc amplificatin may play a role of positive regulation in the lymph metastasis of laryngeal cancer.The abnormal amplification of Myc gene family is one of the causes in development of laryngeal cancer. |
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| Keywords: | Laryngeal neoplasms Genes myc Neoplasm metastasis Amplification |
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