硫辛酸对慢性酒精性周围神经病同型半胱氨酸、超敏C反应蛋白及临床症状的作用

目的观察硫辛酸对慢性酒精性周围神经病(CAPN)的同型半胱氨酸(HCY)、超敏C反应蛋白(Hs-CRP)及临床症状的作用。方法将46例CAPN患者随机分为治疗组和对照组,治疗组给予硫辛酸静脉滴注,0.6 g/d;对照组给予甲钴胺注射液避光静脉滴注500 ug/d,连用14 d,比较两组患者治疗前、治疗后HCY及HsCRP及变化,并以神经系统症状评分,以评价其疗效。结果治疗后2组患者HCY及Hs-CRP水平明显降低,与治疗前比较,差异有统计学意(P0.05),且治疗组Hs-CRP及Hs-CRP水平显著低于对照组,差异有统计学意义(P0.05);治疗后两组临床症状评分均降低,与治疗前比较,差异有统计学意义(P0.05),且治疗组临床症状评分显著低于对照组,差异有统计学意义(P0.05)。治疗期间2组患者均未出现明显不良反应。结论硫辛酸可降低CAPN患者HCY及Hs-CRP水平,显著改善患者临床症状,值得应用及研究。

The effects of lipoic acid on inflammatory factors and prognosis of chronic alcoholic peripheral neuropathy

Objective To observe the effect of lipoic acid on homocysteine (HCY),hypersensitive C reactive pro-tein ( Hs-CRP) and clinical symptoms of patients with chronic alcoholic peripheral neuropathy ( CAPN) .Methods 46 ca-ses of CAPN patients were randomly divided into treatment group and control group ,the treatment group was given intrave-nous injection of lipoic acid 0.6g/d;the control group was given intravenous infusion of Mecobalamin injection light is 500 ug/d.After 14 days treatment , to compare the changes of HCY and Hs-CRP in two groups , to evaluate the scores of nervous system symptoms and efficacy .Results After treatment,the levels of HCY and Hs-CRP in the two groups were significantly decreased,compared with before treatment,the difference was statistically significant (P<0.05),the levels of HCY and Hs-CRP in the treatment group were significantly lower than those in the control group ,the difference was statisti-cally significant(P<0.05).Compared with before treatment,the clinical symptoms of the two groups were reduced ,the difference was statistically significant (P<0.05),and the treatment group clinical symptom score was significantly lower than the control group,the difference was statistically significant (P<0.05)Conclusion Lipoic acid can reduce the level of HCY and Hs-CRP of CAPN patients ,significantly improve the clinical symptoms of patients .It is beneficial to the prog-nosis,is worthy of large-scale application and research .