阿托伐他汀对冠心病患者介入术后的疗效观察

目的探讨阿托伐他汀对冠心病患者行经皮冠状动脉介入术（PCI）后血脂、炎症因子水平及疗效与安全性。方法选择134例接受PCI成功术后患者并随机分为两组，对照组67例在常规治疗的基础上给予阿托伐他汀20mg／d，观察组67例则在患者则在常规治疗的基础上给予阿托伐他汀80能mg／d，观察两组患者用药前后血脂、血清超敏C反应蛋白的水平（hs-CRP）及心脏事件发生情况等。结果治疗12周后，观察组血脂水平及hs-CRP水平降低均优于对照组（P〈0．05）；观察组再狭窄率为5．97％明显低于对照组19．40％（P〈0．05），观察组左心室射血分数（LVEF）明显高于对照组（P〈0．05）；对照组的心脏缺血事件发生率为14．93％，观察组为4．48％，两组相比较差异有显著性（P〈0．05）。两组均无严重的不良反应发生。结论阿托伐他汀对冠心病患者PCI术后再狭窄具有预防作用，大剂量疗效更显著，安全性好，无严重不良反应。

Observation on curative effect of the atorvastatin treatment for coronary heart disease after traitement interventionnelle

Objective To discuss the curative effect and safety of the atorvastatin treatment for coronary heart disease after percutaneous coronary intervention about blood fat and inQammatory factor. Methods We chose 134 patients with coronary heart disease, who accepted the percutaneous coronary intervention, and were randomly divided into two groups, 67 cases in the control group were treated by the conventional therapy and a- torvastatin 20 mg every day, 67 cases in the observation group were treated by the conventional therapy and ator- vastatin 80 mg every day, observed the blood fat, hypersensitive3 C-reactive protein （hs-CRP）and heart risk event in two groups after using medication. Results After 12 weeks, the level of the blood fat and the level of hs-CRP in the observation group were more excellent than those of the control group （P〈0.05）. The restenosis rate of the observation group was 5.97%, which was lower than that with control group with 19.40% （P〈0.05）, the left ventricular ejection fraction of the observation group was higher than that of the control group （P〈0.05）. The incidence rate of the heart ischemia event of the control group was 14.93% ,the observation group was 4.48%, there were statistical significances between two groups （P〈0.05）. There was no serious untoward effect happening in two groups. Conelusiorts The atorvastatin treatment for coronary heart disease after traitement intervention- nelle with restenosis has preventative effect, the curative effect is excellent with the high dose, good safety, and no serious untoward effect.