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Synthesis and anti-inflammatory activity of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives
Authors:Jakubkiene Virginija  Burbuliene Milda Malvina  Mekuskiene Giedrute  Udrenaite Emilija  Gaidelis Povilas  Vainilavicius Povilas
Affiliation:Faculty of Chemistry, Vilnius University, Naugarduko 24, 2006, Vilnius, Lithuania. virginija.jakubkiene@chf.vu.lt
Abstract:
The synthesis of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives and the results of anti-inflammatory activity in vivo are described. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than acetylsalicylic acid.
Keywords:1,3,4-Oxadiazole-2-thiones   Aminomethylation   Anti-inflammatory activity
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