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| 玻璃体内使用维拉帕米对兔眼视网膜电流图作用电量的研究 | |
| 引用本文： | 刘驰,于秀玲,刘哲丽. 玻璃体内使用维拉帕米对兔眼视网膜电流图作用电量的研究[J]. 中国医科大学学报, 2005, 34(2): 134-135 |
| 作者姓名： | 刘驰 于秀玲 刘哲丽 |
| 作者单位： | 1. 沈阳市第四人民医院眼科 2. 中国医科大学附属第一医院眼科,辽宁,沈阳,110001 |
| 摘 要： | 目的:探讨玻璃体内使用不同浓度的维拉帕米对兔眼视网膜电流图的影响.方法:采用纯系日本大耳白兔共9只,随机分成3组,每组6只眼,向玻璃体内注入不同浓度的维拉帕米溶液.术前、术后进行视网膜电流图检查及眼底检查.结果:各用药组暗适应视网膜电流图最大反应b波振幅的测定值与用药前比较,无显著性差异(P＞0.05).结论:玻璃体内注入1.0 mg维拉帕米对兔眼及其视网膜电流图无影响.维拉帕米可用于眼底增殖性疾病治疗的研究. |
| 关 键 词： | 增殖性玻璃体视网膜病变 维拉帕米 视网膜电流图 |
| 文章编号： | 0258-4646(2005)02-0134-02 |
| 修稿时间： | 2004-10-29 |
Effect of verapamil through intravitreal injection on retina of rabbit |
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| LIU Chi,YU Xiu-ling,LIU Zhe-li. Effect of verapamil through intravitreal injection on retina of rabbit[J]. Journal of China Medical University, 2005, 34(2): 134-135 | |
| Authors: | LIU Chi YU Xiu-ling LIU Zhe-li |
| Abstract: | Objective: To investigate the retinal toxicity of verepamil through intravitreal injevtion. Methods: Nine white rabbits were randomly divided into 3 groups, which received intravitreal injection of verapamil of different dosage. Ophthalmoscopy and electroretinography (ERG) were performed after drug injection. Results: There was no difference in b-wave anplitudes in the control and verapamil treated groups. Conclusion: Verapamil of 1.0 mg through intravitreal injection had no retinal toxic effect.This study may provide a baseline for further clinic investigation, and verapamil may be used to treat proliferative eye diseases. |
| Keywords: | proliferative vitreoretinopathy verapamil electroretinography |
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